System and method for compounding low-frequency sources for high-frequency neuromodulation

• US 9,339,655 B2
• Filed: 06/28/2013
• Issued: 05/17/2016
• Est. Priority Date: 06/30/2012
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Carbunaru, Rafael
• Primary Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US13/931,090
• Publication Number:
  US 20140005753A1
• Time in Patent Office: 1,054 Days
• Field of Search: 607/46, 607/66, 607 68- 70
• US Class Current: 1/1
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36003 of motor muscles, e.g. for walking assistance
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36171 Frequency
• CPC Class Codes: A61N 1/36178 Burst or pulse train parameters
• CPC Class Codes: A61N 1/36189 using modulation techniques
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means
• CPC Class Codes: A61N 1/3956 Implantable devices for applying electric shocks to the heart, e.g. for cardioversion

Abstract

A neuromodulation system and method of providing therapy to a patient. A plurality of individual electrical pulse trains is generated at a respective plurality of individual pulse rates. The plurality of individual electrical pulse trains are concurrently respectively from a plurality of electrodes to a common electrode via tissue of the patient, thereby creating a combined electrical pulse train having an average pulse rate equal to or greater than 1 KHz.

Claims

1. A method comprising:

treating chronic pain using a plurality of electrodes, including providing a high-frequency neuromodulation therapy to therapeutically modulate a volume of spinal cord tissue to treat chronic pain without causing paresthesia, the plurality of electrodes including a common electrode and at least two electrodes different than the common electrode,

wherein providing the high-frequency neuromodulation therapy includes;

placing the common electrode adjacent to the volume of spinal cord tissue to be therapeutically modulated to treat chronic pain; and

delivering a combined electrical pulse train having an average pulse rate equal to or greater than 1 KHz, wherein delivering the combined electrical pulse train includes respectively delivering at least two electrical pulse trains from the at least two electrodes to the common electrode to provide the combined electrical pulse train from the common electrode to the volume of tissue to be modulated to treat chronic pain without causing paresthesia, wherein each of the at least two electrical pulse trains are concurrently delivered to the common electrode and have an average pulse rate less than the average pulse rate of the combined electrical pulse train.

2. The method of claim 1, wherein the average pulse rate of the combined electrical pulse train is less than 50 KHz.

3. The method of claim 1, wherein the combined electrical pulse train at the common electrical terminal is anodic.

4. The method of claim 1, wherein the average pulse rate of the combined electrical pulse train is equal to the sum of pulse rates for the at least two electrical pulse trains.

5. The method of claim 1, wherein the at least two electrical pulses trains have identical pulse rates.

6. The method of claim 1, wherein the at least two electrical pulse trains have pulse rates that differ from each other.

7. The method of claim 1, wherein the plurality of electrodes include another common electrode and another at least two electrodes, the method further comprising placing the other common electrode adjacent to the volume of spinal cord tissue to be therapeutically modulated, and delivering another combined electrical pulse train at the other common electrode, the other combined electrical pulse train having another average pulse rate greater than 1 KHz, wherein delivering the other combined electrical pulse train includes concurrently delivering at least two electrical pulse trains from the other at least two of electrodes to the other common electrode.

8. The method of claim 1, wherein the electrical pulse trains are generated using a single electrical source.

9. The method of claim 1, wherein the electrical pulse trains are generated using a plurality of electrical sources.

10. The method of claim 1, further comprising receiving an input from a user, via a user interface, identifying the common electrode.

11. The method of claim 10, wherein further comprising automatically selecting the at least two electrodes in response to the input from the user identifying the common electrode.

12. The method of claim 10, further comprising receiving an input from the user specifying the at least two electrodes.

13. The method of claim 10, further comprising receiving an input from the user specifying an electrode to be excluded, wherein selecting the at least two electrodes excludes the electrode to be excluded specified by the user.

14. The method of claim 1, wherein the at least two electrical pulse trains have different values for a modulation parameter that comprises one of a pulse amplitude, pulse duration, and pulse shape.

15. The method of claim 1, further comprising uniformly spacing pulses of each respective individual electrical pulse train from each other.

16. The method of claim 1, wherein further comprising variably spacing pulses of at least one of the electrical pulse trains in a manner that limits the time intervals between the pulses of the combined electrical pulse train to a minimum time interval.

17. The method of claim 1, wherein at least one pulse in each of the plurality of individual electrical pulse trains is multiphasic.

18. The method of claim 1, further comprising generating each of the individual electrical pulse trains in accordance with a cyclically varying set of modulation parameters.

19. The method of claim 1, wherein further comprising repeatedly generating the electrical pulse trains in a bursting pattern.

20. A method, comprising:

treating chronic pain using a plurality of electrodes, including providing a high-frequency neuromodulation therapy to therapeutically modulate a volume of spinal cord tissue to treat chronic pain without causing paresthesia, the plurality of electrodes including a first common electrode and a second common electrode and a first group of at least two electrodes different than the first common electrode and a second group of at least two electrodes different than the second common electrode,

wherein providing the high-frequency neuromodulation therapy includes;

placing the first common electrode adjacent to the volume of spinal cord tissue to be therapeutically modulated and placing the second common electrode adjacent to the volume of spinal cord tissue to be therapeutically modulated;

delivering both a first combined electrical pulse train and a second combined electrical pulse train where each has an average pulse rate equal to or greater than 1, wherein delivering the first combined electrical pulse train includes respectively delivering at least two electrical pulse trains from the first group of at least two electrodes to the first common electrode to provide the first combined electrical pulse train from the first common electrode to the volume of spinal cord tissue to be modulated, wherein delivering the second combined electrical pulse train includes respectively delivering at least two electrical pulse trains from the second group of at least two of electrodes to the second common electrode to provide the second combined electrical pulse train from the second common electrode to the volume of spinal cord tissue to be modulated wherein each of the at least two electrical pulse trains of each group are concurrently delivered to their respective common electrode and each have an average pulse rate less than the average pulse rate of each respective combined electrical pulse train,

wherein each of the individual electrical pulse trains is generated in accordance with a cyclically varying set of modulation parameters, and

wherein the first and second combined electrical pulse trains for the high-frequency neuromodulation therapy are used to block or otherwise disrupt naturally occurring action potentials within neural fibers to treat chronic pain without causing paresthesia.