Electrode array device having an adsorbed porous reaction layer
First Claim
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1. A device for improved electrochemical synthesis comprising:
- (a) a substrate including a top surface, one or more recesses arranged at the top surface and a plurality of electrodes sunken in the one or more recesses, where the plurality of electrodes have a top electrode surface, where the top electrode surface is level with the top surface, where the substrate is a semiconductor chip or wafer;
(b) a chemical species or mixture of chemical species adsorbed onto the top electrode surface of each electrode of the plurality of electrodes, where the chemical species or mixture of chemical species adsorbed onto the top electrode surface forms a porous matrix;
(c) a semiconductor addressing system for selecting and controlling one or more individual electrodes within the plurality of electrodes, where a synthesis solution covers the porous matrix in contact with the plurality of electrodes;
(d) a source to supply a current, where the source is electronically connected to each of the plurality of electrodes by the semiconductor addressing system; and
(e) a computer control system, where the source is electronically connected to each of the plurality of electrodes via the computer control system, where the computer control system is configured such that the current generates a reactive species, where the generation of the reactive species at each electrode forms a virtual flask surrounding each electrode, where electrochemical synthesis reactions occur within the porous matrix in the virtual flask.
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Abstract
There is disclosed an electrode array device having an adsorbed porous reaction layer for improved synthesis quality. The array comprises a plurality of electrodes on a substrate, wherein the electrodes are electronically connected to a computer control system. The array has an adsorbed porous reaction layer on the plurality of electrodes, wherein the adsorbed porous reaction layer comprises a chemical species having at least one hydroxyl group. In the preferred embodiment, the reaction layer is sucrose. A method for preparing an electrode array for improved synthesis quality is disclosed. The method comprises a cleaning method and a method of attachment of a reaction layer. The cleaning method comprises a plasma cleaning method and a chemical cleaning method. The reaction layer is attached after cleaning by exposing the microarray to a solution containing the chemical species having at least one hydroxyl group.
58 Citations
11 Claims
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1. A device for improved electrochemical synthesis comprising:
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(a) a substrate including a top surface, one or more recesses arranged at the top surface and a plurality of electrodes sunken in the one or more recesses, where the plurality of electrodes have a top electrode surface, where the top electrode surface is level with the top surface, where the substrate is a semiconductor chip or wafer; (b) a chemical species or mixture of chemical species adsorbed onto the top electrode surface of each electrode of the plurality of electrodes, where the chemical species or mixture of chemical species adsorbed onto the top electrode surface forms a porous matrix; (c) a semiconductor addressing system for selecting and controlling one or more individual electrodes within the plurality of electrodes, where a synthesis solution covers the porous matrix in contact with the plurality of electrodes; (d) a source to supply a current, where the source is electronically connected to each of the plurality of electrodes by the semiconductor addressing system; and (e) a computer control system, where the source is electronically connected to each of the plurality of electrodes via the computer control system, where the computer control system is configured such that the current generates a reactive species, where the generation of the reactive species at each electrode forms a virtual flask surrounding each electrode, where electrochemical synthesis reactions occur within the porous matrix in the virtual flask. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification
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Current AssigneeCustomArray, Inc. (Genscript Biotech Corp.)
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Original AssigneeCustomArray, Inc. (Genscript Biotech Corp.)
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InventorsGindilis, Andrei
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Primary Examiner(s)LEVKOVICH, NATALIA A
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Application NumberUS14/082,971Time in Patent Office911 DaysField of Search506/37, 506/19, 506/42, 422/67US Class Current1/1CPC Class CodesB01J 19/0046 Sequential or parallel reac...B01J 2219/00596 Solid-phase processesB01J 2219/00605 the compounds being directl...B01J 2219/00612 the surface being inorganicB01J 2219/00617 by chemical meansB01J 2219/00621 by physical means, e.g. tre...B01J 2219/00626 CovalentB01J 2219/00628 IonicB01J 2219/00637 by coating it with another ...B01J 2219/00641 the porous medium being con...B01J 2219/00653 the compounds being bound t...B01J 2219/00659 Two-dimensional arraysB01J 2219/00722 NucleotidesB01J 2219/00725 PeptidesB08B 3/08 the liquid having chemical ...C23C 26/00 Coating not provided for in...C23F 4/00 Processes for removing meta...C25F 1/00 Electrolytic cleaning, degr...C25F 7/00 Constructional parts, or as...C40B 40/06 Libraries containing nucleo...
