Pharmaceutical compositions for the coordinated delivery of NSAIDs

  • US 9,345,695 B2
  • Filed: 11/30/2015
  • Issued: 05/24/2016
  • Est. Priority Date: 06/01/2001
  • Status: Active Grant
First Claim
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1. A pharmaceutical composition in unit dosage form comprising therapeutically effective amounts of:

  • (a) esomeprazole, wherein at least a portion of said esomeprazole is not surrounded by an enteric coating; and

    (b) naproxen surrounded by a coating that inhibits its release from said unit dosage form unless said dosage form is in a medium with a pH of 3.5 or higher wherein said coating comprises methacrylic acid copolymers;

    wherein said unit dosage form provides for release of said esomeprazole such that upon introduction of said unit dosage form into a medium, at least a portion of said esomeprazole is released regardless of the pH of the medium.

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