Oxygen diffusive wound dressings and methods of manufacturing and use

• US 9,345,869 B2
• Filed: 10/11/2012
• Issued: 05/24/2016
• Est. Priority Date: 10/11/2012
• Status: Active Grant

• Current Assignee: Hanuman Pelican Inc.
• Original Assignee: Owl Manor Medical, LLC
• Inventors: Dorian, Randy, Izvorski, Alexander B., Storrs, Richard W.
• Primary Examiner(s): LEWIS, KIM M
• Application Number:
  US13/650,003
• Publication Number:
  US 20140107562A1
• Time in Patent Office: 1,321 Days
• Field of Search: 602 41- 43, 602/46, 602/47, 602/48, 602/52, 604304-308, 604289-291
• US Class Current: 1/1
• CPC Class Codes: A61F 13/00991 for treating webs, e.g. for moisturising, coating, impregnating or applying powder
• CPC Class Codes: A61F 13/00995 for mechanical treatments
• CPC Class Codes: A61F 13/01021 characterised by the structure of the dressing
• CPC Class Codes: A61F 13/01029 made of multiple layers
• CPC Class Codes: A61F 13/01042 Absorbency
• CPC Class Codes: A61F 13/01046 Air-vapor permeability
• CPC Class Codes: A61F 13/05 specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
• CPC Class Codes: A61M 1/915 Constructional details of the pressure distribution manifold
• CPC Class Codes: A61M 1/92 with liquid supply means
• CPC Class Codes: A61M 1/94 with gas supply means
• CPC Class Codes: A61M 1/985 the dressing itself forming the collection container
• CPC Class Codes: A61M 2202/0208 Oxygen
• CPC Class Codes: A61M 2207/00 Methods of manufacture, assembly or production
• CPC Class Codes: A61M 35/30 Gas therapy for therapeutic treatment of the skin
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04

Abstract

Oxygen diffusive wound dressings and methods of manufacturing and use are described herein. The wound dressing may generally provide a ready supply of oxygen to a wound being treated via one or more oxygen conduits which are designed to pass oxygen from ambient air or other oxygen reservoirs into proximity to the wound, and may also provide for exudate removal through transecting channels in fluid communication with both the wound surface and a hydrophilic absorbent material.

Claims

1. A wound dressing, comprising:

a hydrophilic absorbent material;

a hydrophilic absorbent material envelope which defines an open area for contacting a wound site and which at least partially encloses the hydrophilic absorbent material; and

at least one conduit having an oxygen-diffusive coating and a lumen which allows diffusion of oxygen or oxygenated fluid along its length,

wherein at least one area of the conduit is positioned to extend exposed along the open area in contact with the wound site and adjacent to the hydrophilic absorbent material such that the wound site and hydrophilic absorbent material are in fluid communication, and wherein the at least one conduit has at least one portion further exposed to ambient air.

2. The dressing of claim 1 wherein the hydrophilic absorbent material envelope impedes water vapor transmission.

3. The dressing of claim 1 further comprising at least one multifilament fiber positioned through the at least one conduit.

4. The dressing of claim 1 further comprising at least one hydrophilic element interspersed with the at least one conduit.

5. The dressing of claim 1 wherein the hydrophilic absorbent material is removable and/or replaceable from the hydrophilic absorbent material envelope.

6. The dressing of claim 1 wherein the at least one conduit comprises a diameter range from 40 to 2000 micron.

7. The dressing of claim 6 wherein the at least one conduit comprises a diameter range from 80 to 260 micron.

8. The dressing of claim 1 wherein the oxygen-diffusive coating has a thickness of about 50 to 300 micron.

9. The dressing of claim 1 wherein the oxygen-diffusive coating is comprised of silicone.

10. The dressing of claim 1 wherein the oxygen-diffusive coating defines one or more micro-perforations which are sized to exclude aqueous fluid permeation via surface tension effects.

11. The dressing of claim 1 wherein the oxygen-diffusive coating has an external surface which is modified to be hydrophilic.

12. The dressing of claim 1 wherein the hydrophilic absorbent material envelope comprises an oxygen permeable material.

13. The dressing of claim 1 further comprising an access port upon the hydrophilic absorbent material envelope which is in fluid communication with the hydrophilic absorbent material.

14. The dressing of claim 13 further comprising a vacuum apparatus fluidly coupled to the access port for removing exudate from the wound dressing.

15. The dressing of claim 13 wherein the access port can be reversibly opened to permit evaporation of water from the hydrophilic absorbent material.

16. The dressing of claim 1 further comprising an adhesive border formed around a periphery of the wound dressing.

17. The dressing of claim 1 further comprising a drug, medicant or agent infused into the hydrophilic absorbent material.

18. The dressing of claim 1 further comprising a plurality of additional conduits each having an oxygen-diffusive coating.

19. The dressing of claim 18 wherein the plurality of additional conduits are formed transversely relative to one another.

20. The dressing of claim 18 further comprising one or more oxygen permeable adhesive stripes formed transversely relative to lengths of the conduits.

21. The dressing of claim 1 further comprising a perforated or semi-permeable membrane over the open area for contacting the wound site.

22. The dressing of claim 21 further comprising one or more channels formed through the perforated or semi-permeable membrane and positioned to fluidly couple the wound site and the hydrophilic absorbent material.

23. The dressing of claim 21 wherein the perforated or semi-permeable membrane defines one or more ridges or notches to form the at least one conduit.

24. The dressing of claim 1 further comprising a pump in fluid communication with the at least one conduit.

25. The dressing of claim 1 wherein the dressing further comprises an agent that is adapted to be applied to the wound site, wherein the agent is selected from the group consisting of platelet gel, plasma concentrate, white cells, stem cells, skin grafts, and growth factors.

26. A wound dressing, comprising:

a hydrophilic absorbent material;

at least one conduit having an oxygen-diffusive coating and a lumen which allows diffusion of oxygen or oxygenated fluid along its length,

wherein at least one area of the conduit is positioned to extend in contact with a wound surface and adjacent to the hydrophilic absorbent material such that the wound surface and hydrophilic absorbent material are in fluid communication, and wherein the at least one conduit has at least one portion further exposed to ambient air.

27. The dressing of claim 26 further comprising a hydrophilic absorbent material envelope which defines an open area for contacting the wound surface and which at least partially encloses the hydrophilic absorbent material, wherein the at least one area of the conduit is exposed along the open area for contact with the wound surface.

28. The dressing of claim 27 wherein the hydrophilic absorbent material envelope impedes water vapor transmission.

29. The dressing of claim 27 wherein the hydrophilic absorbent material is removable and/or replaceable from the hydrophilic absorbent material envelope.

30. The dressing of claim 27 wherein the hydrophilic absorbent material envelope comprises an oxygen permeable material.

31. The dressing of claim 27 further comprising an access port upon the hydrophilic absorbent material envelope which is in fluid communication with the hydrophilic absorbent material.

32. The dressing of claim 31 further comprising a vacuum apparatus fluidly coupled to the access port for removing exudate from the wound dressing.

33. The dressing of claim 31 wherein the access port can be reversibly opened to permit evaporation of water from the hydrophilic absorbent material.

34. The dressing of claim 27 further comprising a perforated or semi-permeable membrane over the open are for contacting the wound surface.

35. The dressing of claim 34 farther comprising one or more channels formed through the perforated or semi-permeable membrane and positioned to fluidly couple the wound surface and the hydrophilic absorbent material.

36. The dressing of claim 34 wherein the perforated or semi-permeable membrane defines one or more ridges or notches which also form the at least one conduit.

37. The dressing of claim 26 further comprising at least one multifilament fiber positioned through the at least one conduit.

38. The dressing of claim 26 further comprising at least one hydrophilic element interspersed with the at least one conduit.

39. The dressing of claim 26 wherein the at least one conduit comprises a diameter range from 40 to 2000 micron.

40. The dressing of claim 39 wherein the at least one conduit comprises a diameter range from 80 to 260 micron.

41. The dressing of claim 26 wherein the oxygen-diffusive coating has a thickness of about 50 to 300 micron.

42. The dressing of claim 26 wherein the oxygen-diffusive coating is comprised of silicone.

43. The dressing of claim 26 wherein the oxygen-diffusive coating defines one or more micro-perforations which are sized to exclude aqueous fluid permeation via surface tension effects.

44. The dressing of claim 26 wherein the oxygen-diffusive coating has an external surface which is modified to be hydrophilic.

45. The dressing of claim 26 further comprising an adhesive border formed around a periphery of the wound dressing.

46. The dressing of claim 26 further comprising a drug, medicant or agent infused into the hydrophilic absorbent material.

47. The dressing of claim 26 further comprising a plurality of additional conduits each having an oxygen-diffusive coating.

48. The dressing of claim 47 wherein the plurality of additional conduits are formed transversely relative to one another.

49. The dressing of claim 47 further comprising one or more oxygen permeable adhesive stripes formed transversely relative to lengths of the conduits.

50. The dressing of claim 26 further comprising a pump in fluid communication with the at least one conduit.

51. The dressing of claim 26 wherein the dressing further comprises an agent that is adapted to be applied to the wound surface, wherein the agent is selected from the group consisting of platelet gel, plasma concentrate, white cells, stem cells, skin grafts, and growth factors.

52. A wound dressing, comprising:

a hydrophilic absorbent material;

at least one oxygen conductive hydrophobic conduit extending therethrough or adjacent therealong of the wound dressing; and

a hydrophilic absorbent material envelope which defines an open area for contacting a wound site and which at least partially encloses the hydrophilic absorbent material,

wherein at least a portion of the at least one oxygen conductive hydrophobic conduit is positioned to extend exposed along the open area in contact with the wound site and adjacent to the hydrophilic absorbent material such that the wound site and hydrophilic absorbent material are in fluid communication; and

wherein at least one area or the at least one oxygen conductive hydrophobic conduit is in contact with ambient air and is permeable to oxygen.

53. The dressing of claim 52 further comprising at least one multifilament fiber positioned through the at least one oxygen conductive hydrophobic conduit.

54. The dressing of claim 52 further comprising at least one hydrophilic element interspersed with the at least one oxygen conductive hydrophobic conduit.

55. The dressing of claim 52 wherein the hydrophilic absorbent material is removable and/or replaceable from the hydrophilic absorbent material envelope.

56. The dressing of claim 52 wherein the at least one oxygen conductive hydrophobic conduit comprises a diameter range from 40 to 2000 micron.

57. The dressing of claim 56, wherein the at least one oxygen conductive hydrophobic conduit comprises a diameter range from 80 to 260 micron.

58. The dressing of claim 52 wherein the oxygen conductive hydrophobic conduit has a thickness of about 50 to 300 micron.

59. The dressing of claim 52 wherein the oxygen conductive hydrophobic conduit is comprised of silicone.

60. The dressing of claim 52 wherein the oxygen conductive hydrophobic conduit defines one or more micro-perforations which are sized to exclude aqueous fluid permeation via surface tension effects.

61. The dressing of claim 52 wherein the oxygen conductive hydrophobic conduit has an oxygen-diffusive coating having and external surface which is modified to be hydrophilic.

62. The dressing of claim 52 wherein the hydrophilic absorbent material envelope comprises an oxygen permeable material.

63. The dressing of claim 52 further comprising an access port upon the hydrophilic absorbent material envelope which is in fluid communication with the hydrophilic absorbent material.

64. The dressing of claim 63 further comprising a vacuum apparatus fluidly coupled to the access port for removing exudate from the wound dressing.

65. The dressing of claim 52 further comprising an adhesive border formed around a periphery of the wound dressing.

66. The dressing of claim 52 further comprising a drug, medicant or agent infused into the hydrophilic absorbent material.

67. The dressing of claim 52 further comprising a plurality of additional conduits each having an oxygen-diffusive covering.

68. The dressing of claim 67 wherein the plurality of additional conduits are formed transversely relative to one another.

69. The dressing of claim 67 further comprising one or more oxygen permeable adhesive stripes formed transversely relative to lengths of the conduits.

70. The dressing of claim 52 further comprising a perforated or semi-permeable membrane over the open area for contacting the wound site.

71. The dressing of claim 70 further comprising one or more channels formed through the perforated or semi-permeable membrane and positioned to fluidly couple the wound site and the hydrophilic absorbent material.

72. The dressing of claim 70 wherein the perforated or semi-permeable membrane also defines one or more ridges or notches to form the at least one conduit.

73. The dressing of claim 52 further comprising a pump in fluid communication with the at least one conduit.

74. The dressing of claim 52 wherein the dressing further comprises an agent that is adapted to be applied to the wound site, wherein the agent is selected from the group consisting of platelet gel, plasma concentrate, white cells, stem cells, skin grafts, and growth factors.

75. A wound dressing, comprising:

at least one conduit having an oxygen-diffusive coating and a lumen which allows diffusion of oxygen or oxygenated fluid along its length, wherein the at least one conduit defines a wound contact region for contact with a wound surface and an oxygen absorption region which is configured to extend beyond the wound surface and is exposed to ambient air; and

an adhesive border formed around a periphery of the wound dressing.

76. The dressing of claim 75 further comprising:

a hydrophilic absorbent material which is in fluid communication with the wound surface; and

a hydrophilic absorbent material envelope which defines an open area for contacting the wound surface and which at least partially encloses the hydrophilic absorbent material.

77. The dressing of claim 76 wherein the hydrophilic absorbent material envelope impedes water vapor transmission.

78. The dressing of claim 76 wherein the hydrophilic absorbent material is removable and/or replaceable from the hydrophilic absorbent material envelope.

79. The dressing of claim 75 wherein the oxygen-diffusive coating is comprised of silicone.

80. The dressing of claim 75 wherein the at least one conduit extends through the adhesive border.

81. A method of treating a wound, comprising:

providing a wound dressing having a hydrophilic absorbent material, a hydrophilic absorbent material envelope which defines an open area for contacting a wound site and which at least partially encloses the hydrophilic absorbent material, and at least one conduit having an oxygen-diffusive coating;

placing the open area upon the wound site such that the at least one conduit is in contact against the wound site and the wound site and hydrophilic absorbent material are in fluid communication; and

diffusing oxygen from the at least one conduit and through the oxygen-diffusive coating to the wound site.

82. The method of claim 81 wherein the at least one conduit is positioned to extend exposed along the open area and adjacent to the hydrophilic absorbent material.

83. The method of claim 81 further wicking exudate from the wound site to the hydrophilic absorbent material.

84. The method of claim 81 wherein placing the open area upon the wound site comprises maintaining a separation between the hydrophilic absorbent material and the wound site.

85. The method of claim 81 wherein the at least one conduit comprises at least one coated multifilament fiber positioned through the at least one conduit.

86. The method of claim 85 wherein prior to providing a wound dressing, permeating the multifilament fiber with a fluid to transiently obstruct open inter-filament spaces before applying the oxygen diffusive coating.

87. The method of claim 81 wherein the wound dressing further comprises at least one hydrophilic element interspersed with the at least one conduit.

88. The method of claim 81 wherein the oxygen-diffusive coating is comprised of silicone.

89. The method of claim 81 further removing excess exudate from the wound site via an access port upon the hydrophilic absorbent material envelope which is in fluid communication with the hydrophilic absorbent material.

90. The method of claim 89 wherein removing excess exudate comprises suctioning the exudate from the wound site.

91. The method of claim 81 wherein placing the open area upon the wound site comprises adhering the wound dressing around a periphery of the wound site via an adhesive border.

92. The method of claim 81 further comprising infusing a drug, medicant or agent into the hydrophilic absorbent material.

93. The method of claim 81 further comprising inhibiting evaporation from the hydrophilic absorbent material via the hydrophilic absorbent material envelope.

94. The method of claim 81 comprising an oxygen delivery system comprising pumping an oxygen-rich fluid through the at least one conduit via a pump or pressurized reservoir.

95. The method of claim 81 further comprising applying a treatment to the wound site selected from the group consisting of platelet gel, plasma concentrate, white cells, stem cells, skin grafts, and growth factors.

96. The method of claim 95 wherein the treatment is applied prior to, during, or after placing the open area upon the wound site.

97. The method of claim 81 further comprising removing the hydrophilic absorbent material from the hydrophilic absorbent material envelope.

98. The method of claim 97 wherein the hydrophilic absorbent material is removed from the hydrophilic absorbent material envelope while maintaining the open area upon the wound site.