Methods and systems for treating a psychotic disorder

• US 9,352,145 B2
• Filed: 07/02/2009
• Issued: 05/31/2016
• Est. Priority Date: 12/22/2004
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Whitehurst, Todd K., Jaax, Kristen N.
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): GHAND, JENNIFER LEIGH-STEWAR
• Application Number:
  US12/497,386
• Publication Number:
  US 20090270944A1
• Time in Patent Office: 2,525 Days
• Field of Search: 600/544, 600/545, 607/2, 607/45, 607/48, 607/59, 607/115, 607/116, 607/139
• US Class Current: 1/1
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

Methods of treating a psychotic disorder include applying at least one stimulus to a stimulation site within a patient with an implanted stimulator in accordance with one or more stimulation parameters configured to treat the psychotic disorder. Systems for treating a psychotic disorder include a stimulator configured to apply at least one stimulus to a stimulation site within a patient in accordance with one or more stimulation parameters configured to treat the psychotic disorder.

Claims

1. A method of treating a psychotic disorder comprising at least one of schizophrenia, a delusional disorder, a schizoaffective disorder, said method comprising:

applying at least one stimulus to a stimulation site within a patient with an implanted stimulator in accordance with one or more stimulation parameters to treat said psychotic disorder; and

sensing at least one indicator related to said psychotic disorder and using said at least one sensed indicator to adjust one or more of said stimulation parameters;

wherein said stimulation site comprises at least one or more of a frontal lobe, temporal lobe, cingulate gyrus, substantia nigra, thalamus, amygdala, hippocampus, ventral tegmental area, nucleus accumbens, and locus coeruleus; and

wherein said at least one indicator comprises a change in cerebrospinal fluid.

2. The method of claim 1, wherein applying the at least one stimulus to the stimulation site within the patient with the implanted stimulator comprises delivering a stimulation current via one or more electrodes coupled to the implanted stimulator.

3. The method of claim 1, wherein applying the at least one stimulus to the stimulation site within the patient with the implanted stimulator comprises a decreased activity of said stimulation site to treat said psychotic disorder.

4. The method of claim 1, wherein applying the at least one stimulus to the stimulation site within the patient with the implanted stimulator comprises an increased activity of said stimulation site to treat said psychotic disorder.

5. The method of claim 1, wherein the stimulus comprises at least one of an electrical stimulation, a drug stimulation, a gene infusion, a chemical stimulation, a thermal stimulation, an electromagnetic stimulation, and a mechanical stimulation.

6. The method of claim 1, further comprising implanting the implanted stimulator at the stimulation site.

7. The method of claim 6, wherein applying the at least one stimulus to the stimulation site within the patient with the implanted stimulator comprises delivering a stimulation current via one or more electrodes coupled to the implanted stimulator, and implanting the implanted stimulator comprises implanting the one or more electrodes in communication with the stimulation site.

8. A method of treating a psychotic disorder comprising at least one of schizophrenia, a delusional disorder, a schizoaffective disorder, said method comprising:

applying at least one stimulus to a stimulation site within a patient with an implanted stimulator in accordance with one or more stimulation parameters to treat said psychotic disorder; and

sensing at least one indicator related to said psychotic disorder and using said at least one sensed indicator to adjust one or more of said stimulation parameters;

wherein said stimulation site comprises at least one or more of a frontal lobe, temporal lobe, cingulate gyrus, substantia nigra, thalamus, amygdala, hippocampus, ventral tegmental area, nucleus accumbens, and locus coeruleus; and

wherein said at least one indicator comprises at least one of an interleukin level, a cytokine level, a lymphokine level, a chemokine level, a growth factor level, an electrolyte level, and an enzyme level.

9. The method of claim 8, wherein applying the at least one stimulus to the stimulation site within the patient with the implanted stimulator comprises delivering a stimulation current via one or more electrodes coupled to the implanted stimulator, and further comprising implanting the one or more electrodes in communication with the stimulation site.

10. The method of claim 8, further comprising implanting the implanted stimulator at the stimulation site.

11. The method of claim 8, wherein said stimulus comprises one or more drugs delivered to said stimulation site.

12. The method of claim 8, wherein said stimulus comprises a stimulation current delivered to said stimulation site and one or more drugs delivered to said stimulation site.