Immunogenic composition

  • US 9,358,279 B2
  • Filed: 10/28/2014
  • Issued: 06/07/2016
  • Est. Priority Date: 06/27/2005
  • Status: Active Grant
First Claim
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1. A process for making an immunogenic composition, said immunogenic composition comprising:

  • a Haemophilus influenza type b (Hib) saccharide conjugate;

    an N. meningitidis capsular saccharide conjugate derived from a strain selected from the group consisting of serogroups A, B, C, W135 and Y;

    whole cell pertussis; and

    hepatitis B surface antigen;

    the method comprising;

    mixing the Hib saccharide conjugate with at least one N meningitidis capsular saccharide conjugate and with the whole cell pertussis and hepatitis B surface antigen to form a composition wherein the saccharide dose of the Hib saccharide conjugate is less than 5 ug and the saccharide does of the N. meningitidis capsular saccharide conjugate is less than 8 μ

    g, and wherein the Geometric Mean Concentration (GMC) for whole cell pertussis or hepatitis B achieved with said immunogenic composition is higher than the GSM achieved after immunisation with said immunogenic composition containing a 5 μ

    g saccharide dose of Hib saccharide conjugate and a 8 μ

    g dose of a N. meningitidis capsular saccharide conjugate.

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