Treatment of pain with topical diclofenac
DC CAFC
First Claim
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1. A method for applying topical agents to a knee of a patient with pain, said method comprising:
- applying a first medication consisting of a topical diclofenac preparation to an area of the knee of said patient to treat osteoarthritis of the knee of said patient, wherein the topical diclofenac preparation consists essentially of 2% w/w diclofenac sodium;
about 40% to about 50% w/w dimethyl sulfoxide;
about 23-29% w/w ethanol;
about 10-12% w/w propylene glycol;
about 0-6% w/w hydroxypropylcellulose; and
water to make 100% w/w; and
wherein the topical diclofenac preparation has a viscosity of 500-5000 centipoise;
waiting for the treated area to dry;
subsequently applying a sunscreen, or an insect repellant to said treated area after said treated area is dry, wherein said step of applying a first medication does not enhance the systemic absorption of the subsequently applied sunscreen, or insect repellant;
wherein said subsequent application occurs during a course of treatment of said patient in which said topical diclofenac preparation is administered twice daily; and
counseling said patient to avoid taking unprescribed acetaminophen while using said topical diclofenac preparation.
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Abstract
The field involves compositions useful for pain relief, including diclofenac solution and gel formulations, in particular methods of use thereof, articles of manufacture and kits that provide novel preclinical, clinical and other information to users.
45 Citations
15 Claims
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1. A method for applying topical agents to a knee of a patient with pain, said method comprising:
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applying a first medication consisting of a topical diclofenac preparation to an area of the knee of said patient to treat osteoarthritis of the knee of said patient, wherein the topical diclofenac preparation consists essentially of 2% w/w diclofenac sodium;
about 40% to about 50% w/w dimethyl sulfoxide;
about 23-29% w/w ethanol;
about 10-12% w/w propylene glycol;
about 0-6% w/w hydroxypropylcellulose; and
water to make 100% w/w; and
wherein the topical diclofenac preparation has a viscosity of 500-5000 centipoise;waiting for the treated area to dry; subsequently applying a sunscreen, or an insect repellant to said treated area after said treated area is dry, wherein said step of applying a first medication does not enhance the systemic absorption of the subsequently applied sunscreen, or insect repellant; wherein said subsequent application occurs during a course of treatment of said patient in which said topical diclofenac preparation is administered twice daily; and counseling said patient to avoid taking unprescribed acetaminophen while using said topical diclofenac preparation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for applying topical agents to a knee of a patient with pain, said method comprising:
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applying a first medication comprising a topical diclofenac preparation to an area of the knee of said patient to treat osteoarthritis of the knee of said patient, wherein the topical diclofenac preparation consists essentially of 2% w/w diclofenac sodium;
about 40% to about 50% w/w dimethyl sulfoxide;
about 23-29% w/w ethanol;
about 10-12% w/w propylene glycol;
about 0-6% w/w hydroxypropylcellulose; and
water to make 100% w/w; and
wherein the topical diclofenac preparation has a viscosity of 500-5000 centipoise;waiting for the treated area to dry; and subsequently applying a second prescription medication consisting of a topical medication other than said first medication to said treated area after said treated area is dry, wherein said subsequent application occurs during a course of treatment of said patient in which said topical diclofenac preparation is administered twice daily; and counseling said patient to avoid taking unprescribed acetaminophen while using said topical diclofenac preparation. - View Dependent Claims (12, 13, 14, 15)
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Specification
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Litigation Data
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Current AssigneeHorizon Therapeutics Ireland Dac
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Original AssigneeHZNP Limited (Amgen Inc.)
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InventorsSingh, Jagat, Shainhouse, Joseph Zev, Galer, Bradley S., King-Smith, Robert Dominic, Grierson, Lisa Marie, Burian, Maria, Wilkin, Jonathan, Kisak, Edward, Newsam, John M.
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Primary Examiner(s)Pihonak, Sarah
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Application NumberUS14/810,129Publication NumberTime in Patent Office337 DaysField of SearchUS Class Current1/1CPC Class CodesA61K 2300/00 Mixtures or combinations of...A61K 31/10 Sulfides; Sulfoxides; SulfonesA61K 31/196 the amino group being direc...A61K 45/06 Mixtures of active ingredie...A61K 47/10 Alcohols; Phenols; Salts th...A61K 47/20 containing sulfur, e.g. dim...A61K 47/38 Cellulose; Derivatives thereofA61K 8/35 Ketones, e.g. benzophenoneA61K 8/36 Carboxylic acids; Salts or ...A61K 8/361 Carboxylic acids having mor...A61K 8/42 AmidesA61K 9/0014 Skin, i.e. galenical aspect...A61P 19/02 for joint disorders, e.g. a...A61P 29/00 Non-central analgesic, anti...A61Q 17/02 containing insect repellantsA61Q 17/04 Topical preparations for af...
