Methods and compositions for the inhibition of fructokinase
First Claim
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1. A method for diminishing, inhibiting or eliminating addiction-related behavior of a human, said method comprisingidentifying said human as having a fructose and/or sucrose addiction;
- and administering to said human an effective amount of a composition comprising a ketohexokinase C (KHK-C) inhibitor to diminish said fructose and/or sucrose addition.
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Abstract
The invention relates to the use of isoform-specific fructokinase (ketohexokinase) (KHK) inhibitors alone or in combination with various agents to both prevent and treat a wide variety of diseases including, but not limited to, sugar craving, obesity, features of metabolic syndrome (including insulin resistance, hypertriglyceridemia, hypertension, and fatty liver), polyuria, proximal tubular injury, and diabetic kidney disease.
10 Citations
8 Claims
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1. A method for diminishing, inhibiting or eliminating addiction-related behavior of a human, said method comprising
identifying said human as having a fructose and/or sucrose addiction; - and administering to said human an effective amount of a composition comprising a ketohexokinase C (KHK-C) inhibitor to diminish said fructose and/or sucrose addition.
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2. A method for treating or protecting against acute kidney injury (AKI) in a subject, the method comprising administering a composition comprising a KHK-C inhibitor;
- wherein said AKI that is treated or protected against is AKI associated with administration of a contrast agent;
AKI associated with cardiovascular surgery;
or AKI associated with sepsis. - View Dependent Claims (3, 4, 5, 6, 7)
- wherein said AKI that is treated or protected against is AKI associated with administration of a contrast agent;
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8. A method of treating diabetic nephropathy in a subject, said method comprising administering a KHK-C inhibitor to the subject, wherein the KHK-C inhibitor does not inhibit KHK-A.
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