Methods for improving drug efficacy including a combination of drug administration and nerve modulation
First Claim
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1. A method for treating a patient having an obstructive lung disease, comprising:
- (a) disrupting nerve activity in a parasympathetic nervous system of the patient to reduce obstruction in a distal airway in a lung of the patient; and
(b) while nerve activity is disrupted and the obstruction is reduced in the distal airway, administering a dose of an anticholinergic drug to the patient, the anticholinergic drug having a reference efficacy,wherein a combination of steps (a) and (b) have a combined treatment efficacy greater than the reference efficacy of the anticholinergic drug.
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Abstract
The present disclosure provides methods for improving drug efficacy in a patient having an obstructed airway in a lung. Such methods modulate nerve activity in the autonomic nervous system of a patient to reduce obstruction of an airway in a lung of the patient prior to administering a drug to the patient. These methods are especially useful in improving efficacies of bronchodilators in treating obstructive lung diseases, such as chronic obstructive pulmonary disease.
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24 Claims
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1. A method for treating a patient having an obstructive lung disease, comprising:
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(a) disrupting nerve activity in a parasympathetic nervous system of the patient to reduce obstruction in a distal airway in a lung of the patient; and (b) while nerve activity is disrupted and the obstruction is reduced in the distal airway, administering a dose of an anticholinergic drug to the patient, the anticholinergic drug having a reference efficacy, wherein a combination of steps (a) and (b) have a combined treatment efficacy greater than the reference efficacy of the anticholinergic drug. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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