Method of treating middle ear infections

  • US 9,402,805 B1
  • Filed: 04/29/2016
  • Issued: 08/02/2016
  • Est. Priority Date: 09/21/2001
  • Status: Active Grant
First Claim
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1. A method of treating a human patient comprising the steps of:

  • (a) diagnosing the patient as having otitis media and an open tympanic membrane and/or having acute otitis externa in at least one ear; and

    (b) topically applying into the ear canal of the patients ear an aqueous suspension composition containing a combination of ciprofloxacin and dexamethasone, wherein the composition comprises a) 0.01-0.5% (wt.) dexamethasone;

    b) 0.1-0.4% (wt.) ciprofloxacin;

    c) 0.1-0.9% (wt.) tonicity agent;

    d) 0.01-0.2% (wt.) of a nonionic surfactant; and

    e) a buffer;

    wherein three or four drops of the aqueous suspension composition are administered to the patients ear twice a day, and wherein each drop is 30-35 μ


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