Pharmaceutical combination for use in glycemic control in diabetes type 2 patients

• US 9,408,893 B2
• Filed: 08/27/2012
• Issued: 08/09/2016
• Est. Priority Date: 08/29/2011
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: Niemeller, Elisabeth, Mehlen-Bartmer, Isabel, Silvestre, Louise, Boka, Gabor, Miossec, Patrick
• Primary Examiner(s): Ha, Julie
• Assistant Examiner(s): KOMATSU, LI N
• Application Number:
  US13/595,590
• Publication Number:
  US 20130203666A1
• Time in Patent Office: 1,443 Days
• US Class Current: 1/1
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/155 Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
• CPC Class Codes: A61K 31/427 not condensed and containing further heterocyclic rings
• CPC Class Codes: A61K 31/4439 containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole nicotine A61K31/465
• CPC Class Codes: A61K 38/26 Glucagons
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention refers to a pharmaceutical combination for use in glycemic control in diabetes type 2 patients.

Claims

1. A method for improvement of glycemic control in a patient having diabetes type 2, comprising administering to the patient a therapeutically effective amount of the pharmaceutical combination comprising:

(a) desPro³⁶Exendin-4(1-39)-Lys₆-NH₂ and/or a pharmaceutically acceptable salt thereof, and

(b) a glitazone and/or a pharmaceutically acceptable salt thereof; and

wherein the patient has a haemoglobin A1c (HbA_1c) value of at least 8% and a fasting plasma glucose of at least 9 mmol/L when treated with glitazone alone.

2. The method of claim 1, wherein the patient is an adult.