Devices, systems and methods for evaluation of hemostasis
First Claim
Patent Images
1. A device for evaluation of hemostasis, comprising:
- a plurality of test chambers each configured to receive blood of a test sample, each test chamber comprising a reagent or combination of reagents, wherein each chamber is configured to be interrogated to determine a hemostatic parameter of the blood received therein;
a first chamber of the plurality comprising a first reagent or a first combination of reagents that interact with the blood received therein, wherein the first reagent, or a reagent included in the first combination of reagents, is an activator of coagulation;
a second chamber of the plurality comprising a second combination of reagents that interact with blood of the test sample received therein, the second combination including an activator of coagulation and one or both of abciximab and cytochalasin D; and
an interrogation device that measures at least one viscoelastic property of the test sample.
1 Assignment
2 Petitions
Accused Products
Abstract
Provided are devices, systems and methods for evaluation of hemostasis. Also provided are sound focusing assemblies.
156 Citations
20 Claims
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1. A device for evaluation of hemostasis, comprising:
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a plurality of test chambers each configured to receive blood of a test sample, each test chamber comprising a reagent or combination of reagents, wherein each chamber is configured to be interrogated to determine a hemostatic parameter of the blood received therein; a first chamber of the plurality comprising a first reagent or a first combination of reagents that interact with the blood received therein, wherein the first reagent, or a reagent included in the first combination of reagents, is an activator of coagulation; a second chamber of the plurality comprising a second combination of reagents that interact with blood of the test sample received therein, the second combination including an activator of coagulation and one or both of abciximab and cytochalasin D; and an interrogation device that measures at least one viscoelastic property of the test sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A system for evaluation of hemostasis comprising:
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a plurality of test chambers each configured to receive blood of a test sample, each test chamber comprising a reagent or combination of reagents; wherein a first chamber of the plurality comprises an activator of coagulation that interact with the blood received therein; wherein a second chamber of the plurality comprises an activator of coagulation and one or both of abciximab and cytochalasin D that interact with blood of the test sample received therein the combination including an activator of coagulation and; wherein the first chamber is configured to be interrogated with ultrasound for a hemostatic parameter of the blood received therein to be determined; wherein the second chamber is configured to be interrogated with ultrasound for a hemostatic parameter of the blood received therein to be determined; a transducer for transmitting ultrasound into one or more test chamber and for receiving reflected ultrasound from the chamber and the sample therein; and at least one processor in communication with the transducer, the processor being configured to determine the hemostatic parameters from signals transmitted to the processor from the transducer. - View Dependent Claims (18, 19, 20)
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Specification