Combination product comprising phentermine and topiramate, and preparation method thereof
First Claim
1. A combination product, which comprises phentermine or salt thereof, and sustained-release pellet of topiramate, wherein the sustained-release pellet of topiramate comprises a blank pellet core, a drug layer and a sustained-release coating layer, wherein the drug layer is free of binding agent selected from the group consisting of starch slurry, syrup, polyvinylpyrrolidone, methyl cellulose (MC), ethyl cellulose (EC), highly-substituted hydroxypropyl cellulose (H-HPC), hydroxypropyl methyl cellulose (HPMC), sodium carboxymethyl cellulose, gelatin, Arabic gum, and a mixture thereof.
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Abstract
The present invention provides a combination product, which comprises immediate release pellet of phentermine and sustained-release pellet of topiramate, wherein the pellet of topiramate includes: a) a blank pellet core; b) an active drug layer that contains topiramate and is free of binding agent, the layer being located on surface of the blank pellet core; c) a sustained-release coating layer containing ethyl cellulose and PVP K30, the sustained-release coating layer being located on external of the active drug layer. The present invention further discloses a method for preparing the combination product.
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25 Claims
- 1. A combination product, which comprises phentermine or salt thereof, and sustained-release pellet of topiramate, wherein the sustained-release pellet of topiramate comprises a blank pellet core, a drug layer and a sustained-release coating layer, wherein the drug layer is free of binding agent selected from the group consisting of starch slurry, syrup, polyvinylpyrrolidone, methyl cellulose (MC), ethyl cellulose (EC), highly-substituted hydroxypropyl cellulose (H-HPC), hydroxypropyl methyl cellulose (HPMC), sodium carboxymethyl cellulose, gelatin, Arabic gum, and a mixture thereof.
Specification