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Combination product comprising phentermine and topiramate, and preparation method thereof

  • US 9,421,188 B2
  • Filed: 03/20/2013
  • Issued: 08/23/2016
  • Est. Priority Date: 03/23/2012
  • Status: Active Grant
First Claim
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1. A combination product, which comprises phentermine or salt thereof, and sustained-release pellet of topiramate, wherein the sustained-release pellet of topiramate comprises a blank pellet core, a drug layer and a sustained-release coating layer, wherein the drug layer is free of binding agent selected from the group consisting of starch slurry, syrup, polyvinylpyrrolidone, methyl cellulose (MC), ethyl cellulose (EC), highly-substituted hydroxypropyl cellulose (H-HPC), hydroxypropyl methyl cellulose (HPMC), sodium carboxymethyl cellulose, gelatin, Arabic gum, and a mixture thereof.

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