Binding of galectin-3 by low molecular weight pectin

• US 9,427,449 B2
• Filed: 06/06/2011
• Issued: 08/30/2016
• Est. Priority Date: 08/26/2005
• Status: Active Grant

• Current Assignee: Econugenics Incorporated, Sony Computer Entertainment Incorporated (Sony Group Corp.)
• Original Assignee: Econugenics Incorporated
• Inventors: Eliaz, Isaac
• Primary Examiner(s): Lewis, Patrick
• Assistant Examiner(s): White, Everett
• Application Number:
  US13/153,648
• Publication Number:
  US 20110294755A1
• Time in Patent Office: 1,912 Days
• Field of Search: 514/54, 536/2, 536/124
• US Class Current: 1/1
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/732 Pectin
• CPC Class Codes: A61K 31/734 Alginic acid
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/04 specific for metastasis
• CPC Class Codes: A61P 37/04 Immunostimulants

Abstract

Administration of low molecular weight (10,000-20,000 Daltons, or lower) pectins, particularly modified citrus pectins (MCP), like PectaSol-C reduces galectins-3 levels in vivo. Reduction of galectin-3 levels by MCP inhibits inflammation, inhibits fibrosis formation in organs and tissues, and inhibits cancer formation, progression, transformation and metastases. The reduction in circulating, serum and cellular galectin-3, inherently resulting from the administration of MCP, provides benefit over a spectrum of biological conditions, as evidenced by in vivo trials.

Claims

1. A method of treating a mammal which benefits from a reduction in available circulating galectin-3, comprising the steps of:

a) Selecting a mammal in need of at least one of inhibition or reduction of inflammation, and

b) Administering to said mammal an amount of modified citrus pectin of molecular weight of 3,000-13,000 Daltons, in an amount of 10-750 mg/kg/day, for a period of time sufficient such that said mammal exhibits a reduction in active galectin-3 levels in said mammal and thereby inhibit in said mammal said inflammation or thereby reduce it.

2. A method of treating a mammal which benefits from a reduction in available galectin-3, comprising the steps of:

a) Selecting a mammal in need of at least one of inhibition and reduction of inflammation, and

b) administering to said mammal an amount of modified citrus pectin of low molecular weight of 10,000-20,000 Daltons, in an amount of 5-1,500 mg/kg/day, for a period of time sufficient for said mammal to exhibit a reduction in active galectin-3 levels in said mammal and thereby inhibit in said mammal said inflammation or thereby reduce it.