Systems and methods for accelerating healing of implanted material and/or native tissue

• US 9,452,302 B2
• Filed: 07/10/2012
• Issued: 09/27/2016
• Est. Priority Date: 07/10/2011
• Status: Active Grant

• Current Assignee: Guided Therapy Systems Llc
• Original Assignee: Guided Therapy Systems Llc
• Inventors: Slayton, Michael H.
• Primary Examiner(s): Holmes, Rex R
• Application Number:
  US13/545,953
• Publication Number:
  US 20130012755A1
• Time in Patent Office: 1,540 Days
• Field of Search: 600/2, 600/9, 600/439, 606/169
• US Class Current: 1/1
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61B 2018/00642 with feedback, i.e. closed loop control
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61N 2007/0004 Applications of ultrasound therapy
• CPC Class Codes: A61N 2007/0017 Wound healing
• CPC Class Codes: A61N 2007/0034 Skin treatment
• CPC Class Codes: A61N 2007/0039 using microbubbles
• CPC Class Codes: A61N 2007/0052 using the same transducer for therapy and imaging
• CPC Class Codes: A61N 2007/006 Lenses
• CPC Class Codes: A61N 2007/0073 using multiple frequencies
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 2007/027 with multiple foci created simultaneously
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

Various embodiments provide methods and systems for ultrasound treatment of tissue are provided. Accordingly, a method can include locating an implant in a site in a body, directing a medicant to at least one of the implant and the site, directing ultrasound energy to the site, and accelerating healing of the implant and/or native tissue at the site.

Claims

1. A method of treating an implant in a region of interest, the method comprising:

targeting an implant comprising a biological material, the implant located in a region of interest comprising tissue;

directing ultrasound energy to the implant comprising the biological material;

effecting the biological material with the ultrasound energy;

creating a therapeutic effect in the tissue in the region of interest with the biological material; and

creating a lesion in the tissue and stimulating a wound healing cascade in the region of interest.

2. The method according to claim 1, wherein the effecting the biological material with the ultrasound energy comprises activating the biological material.

3. The method according to claim 1, wherein the effecting the biological material with the ultrasound energy comprises increasing adoption of the biological material into the tissue.

4. The method according to claim 1, wherein the effecting the biological material with the ultrasound energy comprises potentiating the biological material.

5. The method according to claim 1, the method further comprising creating a conformal region of elevated temperature in the tissue in the region of interest.

6. The method according to claim 1, the method further comprising changing a phase of the biological material with the ultrasound energy.

7. The method according to claim 1, the method further comprising imaging at least one of the implant and the tissue in the region of interest.

8. The method according to claim 1, further comprising directing a second energy into the region of interest and creating a second therapeutic effect in the region of interest with the second energy.

9. The method according to claim 8, wherein the second energy is selected from the group consisting of radiofrequency energy, photon-based energy, plasma-based energy, magnetic resonance energy, microwave energy, mechanical energy, and combinations thereof.

10. The method according to claim 8, wherein the second energy is a second ultrasound energy at a different frequency.

11. The method according to claim 8, wherein the directing the second energy into the region of interest stops the effecting the biological material.

12. The method according to claim 8, wherein the second therapeutic effect in the region of interest is selected from the group consisting of coagulation, increased perfusion, reduction of inflammation, generation of heat shock proteins, initiation of healing cascade, and combinations thereof.

13. A method of treating an implant in a region of interest, the method comprising:

targeting an implant comprising a biological material, the implant located in a region of interest comprising tissue;

directing ultrasound energy to the implant comprising the biological material;

effecting the biological material with the ultrasound energy;

creating a therapeutic effect in the tissue in the region of interest with the biological material; and

directing a second energy into the region of interest and creating a second therapeutic effect in the region of interest with the second energy.

14. The method according to claim 13, wherein the effecting the biological material with the ultrasound energy comprises activating the biological material.

15. The method according to claim 13, wherein the effecting the biological material with the ultrasound energy comprises increasing adoption of the biological material into the tissue.

16. The method according to claim 13, wherein the effecting the biological material with the ultrasound energy comprises potentiating the biological material.

17. The method according to claim 13, the method further comprising creating a conformal region of elevated temperature in the tissue in the region of interest.

18. The method according to claim 13, the method further comprising creating a lesion in the tissue and stimulating a wound healing cascade in the region of interest.

19. The method according to claim 13, the method further comprising changing a phase of the biological material with the ultrasound energy.

20. The method according to claim 13, the method further comprising imaging at least one of the implant and the tissue in the region of interest.

21. The method according to claim 13, wherein the second energy is selected from the group consisting of radiofrequency energy, photon-based energy, plasma-based energy, magnetic resonance energy, microwave energy, mechanical energy, and combinations thereof.

22. The method according to claim 13, wherein the second energy is a second ultrasound energy at a different frequency.

23. The method according to claim 13, wherein the directing the second energy into the region of interest stops the effecting the biological material.

24. The method according to claim 13, wherein the second therapeutic effect in the region is selected from the group consisting of coagulation, increased perfusion, reduction of inflammation, generation of heat shock proteins, initiation of healing cascade, and combinations thereof.