Method and system for targeting the microbiome to promote health and treat allergic and inflammatory diseases

• US 9,457,077 B2
• Filed: 11/30/2015
• Issued: 10/04/2016
• Est. Priority Date: 11/18/2009
• Status: Active Grant

• Current Assignee: Seed Health, Inc.
• Original Assignee: Joseph E. Kovarik, Katherine Rose Kovarik
• Inventors: Kovarik, Katherine Rose, Kovarik, Joseph E.
• Primary Examiner(s): Gangle, Brian J
• Application Number:
  US14/954,074
• Publication Number:
  US 20160074505A1
• Time in Patent Office: 309 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 2039/505 comprising antibodies
• CPC Class Codes: A61K 2039/541 Mucosal route
• CPC Class Codes: A61K 2039/544 to the airways intranasal A61K2039/543
• CPC Class Codes: A61K 2039/55 characterised by the host/recipient, e.g. newborn with maternal antibodies
• CPC Class Codes: A61K 2039/55583 Polysaccharides
• CPC Class Codes: A61K 2039/577 tolerising response
• CPC Class Codes: A61K 2039/58 raising an immune response against a target which is not the antigen used for immunisation
• CPC Class Codes: A61K 2039/70 Multivalent vaccine
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 35/74 Bacteria therapeutic use of a bacterial protein A61K38/00
• CPC Class Codes: A61K 35/741 Probiotics probiotic yeast, e.g. saccharomyces A61K36/06
• CPC Class Codes: A61K 35/742 Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
• CPC Class Codes: A61K 35/745 Bifidobacteria
• CPC Class Codes: A61K 35/747 Lactobacilli, e.g. L. acidophilus or L. brevis
• CPC Class Codes: A61K 39/0008 Antigens related to auto-immune diseases; Preparations to induce self-tolerance
• CPC Class Codes: A61K 39/35 Allergens
• CPC Class Codes: A61K 39/39 characterised by the immunostimulating additives, e.g. chemical adjuvants
• CPC Class Codes: A61K 39/395 Antibodies agglutinins A61K38/36 ; as drug carriers A61K47/50; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0034 Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
• CPC Class Codes: A61K 9/0043 : Nose
• CPC Class Codes: A61K 9/007 : Pulmonary tract; Aromatherapy
• CPC Class Codes: C07K 16/00 : Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies antibodies with enzymatic activity, e.g. abzymes C12N9/0002

Abstract

A method and system for targeting the microbiome to promote health involves exposing an expectant mother to a mixture of farm derived manure-containing soil to reduce the chances her baby will suffer allergies and autoimmune diseases. City dwelling expectant mothers are exposed to immunologic agents and allergens in a fashion (e.g., via exposure to farm animal manure-containing soils) that charges their immune system and that of their fetus(es) so that their babies, once born, are provided with immunity against a variety of autoimmune diseases, including allergies commonly and increasingly experienced in modern urban environments.

Claims

1. A method of reducing a likelihood of an allergic disease developing, comprising:

administering an immune stimulating composition by dispersing, in the air of an urban dwelling where a pregnant human female resides, a prophylactic immune stimulating composition comprising;

at least 5 grams of farm soil having bovine manure components therein, wherein said bovine manure is from a bovine that has not been administered an antibiotic effective against one of Lactobacillus johnsonii, and Bifidobacterium longum bv. Infantis; and

wherein said immune stimulating composition further includes an extract derived from a helminth selected from the group consisting of;

Capillaria hepatica, Dicrocoelium dendriticum, Ascaris lumbricoides, Enterobius vermicularis, Trichuris trichiura, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Haemonchus contortus, and Trichinella spiralis, wherein said step of administering includes exposing an expectant mother to said immune stimulating composition prior to the expectant mother'"'"'s 9th month of pregnancy, wherein said step of exposing comprises inhaling of immune stimulating composition laden air by said expectant mother, said immune stimulating composition laden air generated by flowing air over an exposed portion of said immune stimulating composition inside an enclosed urban dwelling, said expectant mother inhaling said air at least three times a week for at least a 5 minute time period, up until the birth of her baby;

operating an air flow device adapted to convey air about said manure-containing soil into a room; and

wherein said farm soil has bovine manure components including at least one bacteroidetes selected from a phylum of bacteria of the group Bacteroides, Flavobacteria, and Sphingobacteria, and at least one gram-positive firmicute.

2. The method according to claim 1, further comprising providing a container having a chamber that retains a layer of said farm soil, said soil including microorganisms.

3. The method according to claim 1, further comprising providing at least 1000 bacteria added to said immune stimulating composition, said bacteria selected from the group of Bifidobacterium longum biovar infantis, and Lactobacillus johnsonii, and at least 1 gram of a helminthes extract derived from a helminth selected from the group consisting of:

Capillaria hepatica, Dicrocoelium dendriticum, Ascaris lumbricoides, Enterobius vermicularis, Trichuris trichiura, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Haemonchus contortus, Trichinella spiralis and Trichuris suis ova.

4. The method according to claim 1, wherein said expectant mother inhales said air at least three times a week for at least a 5 minute time period, for at least the last trimester of a fetal gestational period.

5. The method according to claim 1, wherein the step of administering comprises including said composition in house plant soils within said urban dwelling.

6. The method according to claim 1, wherein the step of administering comprises inclusion of said immune stimulating composition in a HVAC system within said urban dwelling said immune stimulating composition further comprises cyclodextrin.

7. The method according to claim 1, wherein the bovine manure is from a bovine that has been fed a diet that included at least one arabinogalactan or arabinogalactan protein.

8. The method according to claim 1, wherein the immune stimulating composition further includes a separate additive including at least one arabinogalactan.

9. The method according to claim 1, wherein said step of administering further includes applying to a woman'"'"'s birth canal prior to the birth of her baby a composition including an effective amount of a bacterial formulation that comprises:

Prevotella;

Lactobacillus johnsonii;

Bacteroides fragilis, Lactobacillus ruminus, and an effective amount of an extract derived from a helminth selected from the group consisting of;

Capillaria hepatica, Dicrocoelium dendriticum, Ascaris lumbricoides, Enterobius vermicularis, Trichuris trichiura, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Haemonchus contortus, and Trichinella spiralis.

10. The method of claim 1, wherein the composition has been enhanced by the addition of at least one of the following:

L. infantitis, L. johnsonii, and helminthes.

11. The method of claim 1, wherein the composition comprises an extract derived from at least two of:

Capillaria hepatica, Dicrocoelium dendriticum, Ascaris lumbricoides, Enterobius vermicularis, Trichuris trichiura, Ancylostoma duodenale, Necator americanus;

Strongyloides stercoralis, Haemonchus contortus, and Trichinella spiralis.

12. A method of reducing a likelihood of an allergic disease developing, comprising:

administering an immune stimulating composition by dispersing, in the air of an urban dwelling where a pregnant human female resides, a prophylactic immune stimulating composition comprising;

at least 5 grams of farm soil having bovine manure components therein, wherein said bovine manure is from a bovine that has not been administered an antibiotic effective against one of Lactobacillus johnsonii, and Bifidobacterium longum bv. Infantis; and

wherein said immune stimulating composition further includes an extract derived from a helminth selected from the group consisting of;

Capillaria hepatica, Dicrocoelium dendriticum, Ascaris lumbricoides, Enterobius vermicularis, Trichuris trichiura, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Haemonchus contortus, and Trichinella spiralis, wherein said step of administering includes exposing an expectant mother to said immune stimulating composition prior to the expectant mother'"'"'s 9th month of pregnancy, wherein said step of exposing comprises inhaling of immune stimulating composition laden air by said expectant mother, said immune stimulating composition laden air generated by flowing air over an exposed portion of said immune stimulating composition inside an enclosed urban dwelling, said expectant mother inhaling said air at least three times a week for at least a 5 minute time period, for at least the last trimester of a fetal gestational period; and

wherein said stimulating composition further comprises cyclodextrin.

13. A method of reducing a likelihood of an allergic disease developing, comprising:

administering an immune stimulating composition by dispersing, in the air of an urban dwelling where a pregnant human female resides, a prophylactic immune stimulating composition comprising;

at least 5 grams of farm soil having bovine manure components therein, wherein said bovine manure is from a bovine that has not been administered an antibiotic effective against one of Lactobacillus johnsonii, and Bifidobacterium longum bv. Infantis; and

wherein said immune stimulating composition further includes an extract derived from a helminth selected from the group consisting of;

Capillaria hepatica, Dicrocoelium dendriticum, Ascaris lumbricoides, Enterobius vermicularis, Trichuris trichiura, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Haemonchus contortus, and Trichinella spiralis, wherein said step of administering includes exposing an expectant mother to said immune stimulating composition prior to the expectant mother'"'"'s 9th month of pregnancy, wherein said step of exposing comprises inhaling of immune stimulating composition laden air by said expectant mother, said immune stimulating composition laden air generated by flowing air over an exposed portion of said immune stimulating composition inside an enclosed urban dwelling, said expectant mother inhaling said air at least three times a week for at least a 5 minute time period, for at least the last trimester of a fetal gestational period;

wherein the immune stimulating composition further includes a separate additive including at least one arabinogalactan.

14. A method of reducing a likelihood of an allergic disease developing, comprising:

administering an immune stimulating composition by dispersing, in the air of an urban dwelling where a pregnant human female resides, a prophylactic immune stimulating composition comprising;

at least 5 grams of farm soil having bovine manure components therein, wherein said bovine manure is from a bovine that has not been administered an antibiotic effective against one of Lactobacillus johnsonii, and Bifidobacterium longum bv. Infantis; and

wherein said immune stimulating composition further includes an extract derived from a helminth selected from the group consisting of;

Capillaria hepatica, Dicrocoelium dendriticum, Ascaris lumbricoides, Enterobius vermicularis, Trichuris trichiura, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Haemonchus contortus, and Trichinella spiralis, wherein said step of administering includes exposing an expectant mother to said immune stimulating composition prior to the expectant mother'"'"'s 9th month of pregnancy, wherein said step of exposing comprises inhaling of immune stimulating composition laden air by said expectant mother, said immune stimulating composition laden air generated by flowing air over an exposed portion of said immune stimulating composition inside an enclosed urban dwelling, said expectant mother inhaling said air at least three times a week for at least a 5 minute time period, for at least the last trimester of a fetal gestational period; and

wherein said step of administering further includes applying to a woman'"'"'s birth canal prior to the birth of her baby a composition including an effective amount of a bacterial formulation that comprises;

Prevotella;

Lactobacillus johnsonii;

Bacteroides Lactobacillus ruminus, and an effective amount of an extract derived from a helminth selected from the group consisting of;

Capillaria hepatica, Dicrocoelium dendriticum, Ascaris lumbricoides, Enterobius vermicularis, Trichuris trichiura, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Haemonchus contortus, and Trichinella spiralis.

15. A method of reducing a likelihood of an allergic disease developing, comprising:

administering an immune stimulating composition by dispersing, in the air of an urban dwelling where a pregnant human female resides, a prophylactic immune stimulating composition comprising;

at least 5 grams of farm soil having bovine manure components therein, wherein said bovine manure is from a bovine that has not been administered an antibiotic effective against one of Lactobacillus johnsonii, and Bifidobacterium longum bv, Infantis; and

wherein said immune stimulating composition further includes an extract derived from a helminth selected from the group consisting of;

Capillaria hepatica, Dicrocoelium dendriticum, Ascaris lumbricoides, Enterobius vermicularis, Trichuris trichiura, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Haemonchus contortus, and Trichinella spiralis, wherein said step of administering includes exposing an expectant mother to said immune stimulating composition prior to the expectant mother'"'"'s 9th month of pregnancy, wherein said step of exposing comprises inhaling of immune stimulating composition laden air by said expectant mother, said immune stimulating composition laden air generated by flowing air over an exposed portion of said immune stimulating composition inside an enclosed urban dwelling, said expectant mother inhaling said air at least three times a week for at least a 5 minute time period, for at least the last trimester of a fetal gestational period;

wherein the bovine manure is from a bovine that has been fed a diet that included at least one arabinogalactan or arabinogalactan protein.

16. The method according to claim 15, further comprising operating an air flow device adapted to convey air about said manure-containing soil into a room.

17. The method according to claim 15, wherein said farm soil having bovine manure components therein includes at least one bacerioidetes selected from the phylum of bacteria of the group Bacteroides, Flavobacteria, and Spingobacteria, and at least one gram-positive firmicute wherein said immune stimulating composition further comprises cyclodextrin.

18. The method according to claim 15, wherein the immune stimulating composition further includes a separate additive including at least one arabinogalactan.

19. The method according to claim 15, wherein said step of administering further includes applying to a woman'"'"'s birth canal prior to the birth of her baby a composition including an effective amount of a bacterial formulation that comprises:

Prevotella;

Lactobacillus johnsonii;

Bacteroides fragilis, Lactobacillus ruminus, and an effective amount of an extract derived from a helminth selected from the group consisting of Capillaria hepatica, Dicrocoelium dendriticum, Ascaris lumbricoides, Enterobius vermicularis, Trichuris trichiura, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Haemonchus contortus, and Trichinella spiralis.