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Integrated insulin delivery system with continuous glucose sensor

  • US 9,463,277 B2
  • Filed: 12/30/2013
  • Issued: 10/11/2016
  • Est. Priority Date: 10/09/2007
  • Status: Active Grant
First Claim
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1. An integrated system for monitoring a glucose concentration in a host and for delivering insulin to a host, comprising:

  • a continuous glucose sensor, wherein the continuous glucose sensor is configured to substantially continuously measure a glucose concentration in a host, and to provide sensor data associated with the glucose concentration in the host;

    an electronics module comprising;

    a basal controller module configured to iteratively determine a basal insulin therapy instruction in response to an evaluation of a relationship of internally derived data and a basal profile, wherein the basal profile comprises at least one time block associated with a maximum insulin delivery rate,a bolus controller module configured to iteratively determine a bolus insulin therapy instruction in response to an evaluation of a relationship of internally derived data and an engageable bolus constraint, wherein a relationship of internally derived data to the bolus constraint is evaluated in response to engagement of the bolus constraint, and wherein the bolus constraint comprises a maximum total insulin dose that can be delivered within a predefined time period in response to engagement of the bolus constraint, andan on/off controller module configured to iteratively determine an on/off insulin therapy instruction in response to an evaluation of a relationship of internally derived data and a glucose boundary, wherein the insulin therapy instruction comprises an instruction selected from the group consisting of on and off; and

    an insulin delivery device configured to deliver insulin to the host, wherein the insulin delivery device is at least one of physically connected to a receiver and operably connected to a receiver, wherein the insulin delivery device is configured to receive the insulin therapy instruction from the basal controller module, the bolus controller and/or the on/off controller module.

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