Treatment of heart failure

• US 9,468,634 B2
• Filed: 03/15/2013
• Issued: 10/18/2016
• Est. Priority Date: 11/23/2007
• Status: Expired due to Fees

• Current Assignee: Heart Metabolics Limited (HMBL Ltd.)
• Original Assignee: Heart Metabolics Limited (HMBL Ltd.)
• Inventors: Ashrafian, Houman, Frenneaux, Michael Paul
• Primary Examiner(s): Heyer, Dennis
• Application Number:
  US13/839,313
• Publication Number:
  US 20130210720A1
• Time in Patent Office: 1,313 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 31/4458 only substituted in position 2, e.g. methylphenidate
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/04 Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Abstract

The invention relates to perhexiline, or a pharmaceutically acceptable salt thereof, for use in the treatment of heart failure, as well as to a method for treating heart failure, which comprises administering to an animal in need thereof an effective amount of perhexiline, or a pharmaceutically acceptable salt thereof, to treat said heart failure. The invention further relates to a treatment programme for treating heart failure, which involves the co-use or co-administration of perhexiline with one or more other compounds that are advantageous in treating heart failure or the symptoms thereof.

Claims

1. A method for treating heart failure in a mammal having a left ventricular ejection fraction of at least 50%, said method comprising administering to said mammal an effective amount of perhexiline, or a pharmaceutically acceptable salt thereof, wherein said mammal has diminished exercise capacity or tolerance.

2. The method of claim 1, wherein said mammal has a diminished peak oxygen consumption (VO_2max) during exercise (Aerobic Exercise Capacity) and wherein the effective amount of perhexiline, or a pharmaceutically acceptable salt thereof, is sufficient to increase the peak oxygen consumption (VO_2max) during exercise (Aerobic Exercise Capacity) in the mammal.

3. The method of claim 1, wherein the mammal has no significant left ventricular outflow tract obstruction at rest (gradient <

30 mmHg).

4. The method of claim 1, wherein the perhexiline is in the form of a pharmaceutically acceptable salt.

5. The method of claim 4, wherein the perhexiline is in the form of a maleate salt.

6. The method of claim 1, wherein the mammal is a human.

7. The method of claim 1, further comprising co-administering to said mammal at least one additional therapeutic compound.

8. The method of claim 7, wherein the at least one additional therapeutic compound is selected from a member of the group consisting of Alpha Blockers, Beta Blockers, Calcium Channel Blockers, Diuretics, Ace (Angiotensin-Converting Enzyme) Inhibitors, Arb (Angiotensin II Receptor Blockers), Spironolactone, Nitrate, Warfarin, Verapamil, Insulin, Amiodarone, Lisinopril, Ramipril, Perindopril, Enalapril, Trandolapril, At2 Receptor Blockers, Losartan, Valsartan, Irbersartan, Carvedilol, Bisoprolol, Metoprolol, Atenolol, Aspirin, Clopidogrel, Oral Hypoglycaemics, Disopyramide, and Statins.

9. The method of claim 1, wherein the mammal is further diagnosed as having a member of the group consisting of dyspnea (shortness of breath), chest pain, fatigue, palpitation and syncope.

10. The method of claim 1, wherein the mammal is further diagnosed as having a reduced E:

EA ratio, abnormally rapid skeletal muscle phosphocreatine depletion with delayed recovery, reduced systolic velocity (PSV), or no significant left ventricular outflow tract obstruction at rest (gradient <

30 mmHg).

11. The method of claim 1, wherein perhexiline is administered in an amount of 300 mg per day or less.

12. The method of claim 1, wherein perhexiline is administered in an amount of 100 mg per day or less.

13. The method of claim 1, wherein perhexiline is administered in an amount of 100 mg to 300 mg per day.