In situ reaction device

• US 9,474,712 B2
• Filed: 11/09/2005
• Issued: 10/25/2016
• Est. Priority Date: 11/09/2005
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Inventors: Hood, Leroy E., Ishikawa, Muriel Y., Jung, Edward K. Y., Langer, Robert, Tegreene, Clarence T., Wood, Lowell L. Jr., Wood, Victoria Y. H.
• Primary Examiner(s): Wax, Robert A
• Assistant Examiner(s): HELM, CARALYNNE E
• Application Number:
  US11/272,573
• Publication Number:
  US 20070106276A1
• Time in Patent Office: 4,003 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 41/00 Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 2205/0266 Shape memory materials
• CPC Class Codes: A61M 2205/0288 Electro-rheological or magneto-rheological materials
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2205/36 related to heating or cooling
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: B01J 19/0006 Controlling or regulating processes controlling or regulating in general G05
• CPC Class Codes: B01J 2219/00049 Controlling or regulating processes
• CPC Class Codes: C02F 1/008 Control or steering systems not provided for elsewhere in subclass C02F
• CPC Class Codes: C02F 1/02 by heating methods of steam generation F22B; preheating boiler feed-water or accumulating preheated boiler feed-water F22D
• CPC Class Codes: C02F 1/66 by neutralisation; pH adjustment for degassing C02F1/20; using ion-exchange C02F1/42; for flocculation or precipitation of suspended impurities C02F1/52; for removing dissolved compounds C02F1/58
• CPC Class Codes: C02F 2101/20 : Heavy metals or heavy metal compounds
• CPC Class Codes: C02F 2101/363 : PCB's; PCP's
• CPC Class Codes: C02F 2209/02 : Temperature
• CPC Class Codes: C12N 9/0004 : Oxidoreductases (1.)
• CPC Class Codes: C12N 9/0006 : acting on CH-OH groups as donors (1.1)
• CPC Class Codes: C12N 9/10 : Transferases (2.) ribonucleases C12N9/22
• CPC Class Codes: C12N 9/12 : transferring phosphorus containing groups, e.g. kinases (2.7)
• CPC Class Codes: C12N 9/14 : Hydrolases (3)
• CPC Class Codes: C12N 9/88 : Lyases (4.)
• CPC Class Codes: C12N 9/90 : Isomerases (5.)
• CPC Class Codes: C12N 9/93 : Ligases (6)
• CPC Class Codes: G08C 17/02 : using a radio link

Abstract

Embodiments of a system including a remotely controlled reaction device and associated controller are described. Methods of use and control of the device are also disclosed. According to various embodiments, a reaction device is placed in an environment in order to perform a chemical reaction in an environment. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. In selected embodiments, a magnetic field, an electric field, or electromagnetic control signal may be used.

Claims

1. A reaction device comprising:

a body structure adapted for positioning in a body of an organism;

a reaction region located within the body structure on an inner surface of the reaction device or on the exterior of the body structure and operably coupled thereto, the reaction region including a first material located at and operably coupled to the reaction region and capable of influencing a chemical reaction at the reaction region; and

a remotely activatable control element physically coupled to the reaction region and responsive to an electromagnetic field control signal by changing in at least one dimension to produce a corresponding change in dimension of the reaction region, to thereby produce a modification to one or more of the rate or kinetics of the chemical reaction at the reaction region, wherein a surface area of the reaction region is increased by stretching of at least a portion of the reaction area responsive to the change in at least one dimension of the remotely activatable control element.

2. The reaction device of claim 1, wherein additional portions of the reaction region are exposed responsive to the change in at least one dimension of the remotely activatable control element.

3. The reaction device of claim 2, wherein exposure of additional portions of the reaction region exposes additional functional groups on the reaction region.

4. The reaction device of claim 3, wherein exposure of additional portions of the reaction region exposes additional functional groups on the reaction region to produce at least a local change in pH.

5. The reaction device of claim 3, wherein exposure of additional portions of the reaction region exposes additional functional groups on the reaction region to produce at least a local change in surface energy.

6. The reaction device of claim 3, wherein exposure of additional portions of the reaction region exposes additional functional groups on the reaction region to produce at least a local change in surface charge.

7. The reaction device of claim 1, wherein a volume containing the reaction region within the interior portion of the body structure is increased responsive to the change in at least one dimension of the remotely activatable control element.

8. The reaction device of claim 1, wherein the remotely activatable control element includes at least one of a shape memory material or a bimetallic structure.

9. A reaction device comprising:

a body structure adapted for positioning in an environment;

a reaction region located within the body structure on an inner surface of the reaction device or on the exterior of the body structure and operably coupled thereto, the reaction region including a first material located at and operably coupled to the reaction region and capable of influencing a chemical reaction at the reaction region; and

a remotely activatable control element physically coupled to the reaction region and responsive to input of energy from an electromagnetic field control signal by changing in at least one dimension to produce a corresponding change in dimension of the reaction region, to modify thereby one or more of the rate or kinetics of the chemical reaction at the reaction region through at least one of a mechanical, thermal or chemical mechanism, wherein the remotely activatable control element includes at least one of a shape memory material or a bimetallic structure, and wherein additional portions of the reaction region are exposed responsive to the change in at least one dimension of the remotely activatable control element.

10. The reaction device of claim 9, wherein a surface area of the reaction region is increased responsive to the change in at least one dimension of the remotely activatable control element.

11. The reaction device of claim 10, wherein the surface area of the reaction area is increased by stretching of at least a portion of the reaction area.

12. The reaction device of claim 10, wherein the surface area of the reaction area is increased by unfolding of at least a portion of the reaction area to expose additional portions of the reaction area.

13. The reaction device of claim 9, wherein a volume containing the reaction region within the interior portion of the body structure is modified responsive to the change in at least one dimension of the remotely activatable control element.

14. The reaction device of claim 9, wherein exposure of additional portions of the reaction region exposes additional functional groups to produce at least a local change in osmolality.

15. The reaction device of claim 9, wherein exposure of additional portions of the reaction region exposes additional functional groups on the reaction region.

16. The reaction device of claim 15, wherein exposure of additional portions of the reaction region exposes additional functional groups on the reaction region to produce at least a local change in pH.

17. The reaction device of claim 15, wherein exposure of additional portions of the reaction region exposes additional functional groups on the reaction region to produce at least a local change in surface energy.

18. The reaction device of claim 15, wherein exposure of additional portions of the reaction region exposes additional functional groups on the reaction region to produce at least a local change in surface charge.

19. A reaction system comprising:

a reaction device including;

a body structure adapted for positioning in a body of an organism;

a reaction region located within the body structure on an inner surface of the reaction device or on the exterior of the body structure and operably coupled thereto, the reaction region including a first material located at and operably coupled to the reaction region and capable of influencing a chemical reaction at the reaction region; and

a remotely activatable control element physically coupled to the reaction region and responsive to an electromagnetic field control signal by changing in at least one dimension to produce a corresponding change in dimension of the reaction region, to thereby modify one or more of the rate or kinetics of the chemical reaction at the reaction region, wherein a surface area of the reaction region is increased by unfolding of at least a portion of the reaction area to expose additional portions of the reaction area, responsive to the change in at least one dimension of the remotely activatable control element; and

a remote control signal source capable of generating the electromagnetic control signal sufficient to activate the remotely activatable control element to produce a desired rate or kinetics of the chemical reaction.

20. The reaction system of claim 19, wherein the volume of a reaction space containing the reaction region within the interior portion of the body structure is modified responsive to the change in at least one dimension of the remotely activatable control element.

21. The reaction system of claim 19, wherein said remote control signal source includes at least one of hardware, firmware, or software configured to control generation of the electromagnetic control signal.