Sensing probe comprising multiple, spatially separate, sensing sites
First Claim
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1. A method comprising:
- detecting signals via a sensing probe comprising a plurality of electrical conductors, wherein each conductor of the plurality of electrical conductors comprises a plurality of sensing sites, spatially separate combined sensing sites are formed from the plurality of sensing sites by proximate portions of multiple electrical conductors of the plurality of electrical conductors, and no two combined sensing sites are formed by a same combination of electrical conductors, and wherein the detected signals are indicative of neural activity; and
combinatorially unmixing the detected signals to determine a source of the neural activity, wherein a configuration of the plurality of electrical conductors of the sensing probe is application configurable.
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Abstract
A single sensing probe comprising multiple, spatially separate, sensing sites is utilized to sense neural activity. The sensing probe includes multiple conductors each with multiple sensing sites in a fixed geometric arrangement. The sensing probe is configured to comprise multiple combined sensing sites in polytrode configuration. By appropriately combining the wire groupings at each combined sensing site, activity sensed from a single wire with multiple sensing sites, can be coupled with other wires to unmix signals from the spatially separate sites and leverage the power of combinatorics to maximize total recording bandwidth and single neuron/unit yield per wire and per probe.
32 Citations
18 Claims
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1. A method comprising:
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detecting signals via a sensing probe comprising a plurality of electrical conductors, wherein each conductor of the plurality of electrical conductors comprises a plurality of sensing sites, spatially separate combined sensing sites are formed from the plurality of sensing sites by proximate portions of multiple electrical conductors of the plurality of electrical conductors, and no two combined sensing sites are formed by a same combination of electrical conductors, and wherein the detected signals are indicative of neural activity; and combinatorially unmixing the detected signals to determine a source of the neural activity, wherein a configuration of the plurality of electrical conductors of the sensing probe is application configurable. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method comprising:
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detecting signals via a sensing probe comprising a plurality of electrical conductors, wherein each conductor of the plurality of electrical conductors comprises a plurality of sensing sites, spatially separate combined sensing sites are formed from the plurality of sensing sites by proximate portions of multiple electrical conductors of the plurality of electrical conductors, and no two combined sensing sites are formed by a same combination of electrical conductors, and wherein the detected signals are indicative of neural activity; and combinatorially unmixing the detected signals to determine a source of the neural activity, wherein a mechanical property of the sensing probe is application adjustable. - View Dependent Claims (13, 14, 15, 16, 17, 18)
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Specification