Methods for preparation of medical dressing containing antimicrobial agent

• US 9,480,770 B2
• Filed: 02/28/2014
• Issued: 11/01/2016
• Est. Priority Date: 10/23/2002
• Status: Expired due to Term

• Current Assignee: Kpr U.S., LLC (Cardinal Health, Inc.)
• Original Assignee: Covidien LP (Medtronic Plc)
• Inventors: Patel, Harish A.
• Primary Examiner(s): Su, Susan
• Application Number:
  US14/192,937
• Publication Number:
  US 20140178564A1
• Time in Patent Office: 977 Days
• US Class Current: 1/1
• CPC Class Codes: A61F 13/00063 comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic drug delivery dressings A61K9/70; chemical aspect of the additives A61L15/00
• CPC Class Codes: A61F 13/01008 characterised by the material
• CPC Class Codes: A61F 13/01029 made of multiple layers
• CPC Class Codes: A61F 2013/00604 Multilayer
• CPC Class Codes: A61F 2013/0091 with disinfecting or anaesthetics means, e.g. anti-mycrobic
• CPC Class Codes: A61L 15/225 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: A61P 31/04 Antibacterial agents

Abstract

A medical dressing containing an antimicrobial agent is disclosed. The medical dressing comprises a layered fabric comprising an inner layer of substantially hydrophilic material, an outer layer of substantially hydrophobic material on both sides of the inner layer; and an antimicrobial agent. The antimicrobial agent may be releasably impregnated into the fabric, coated on said fabric or a combination thereof. The antimicrobial agent may be a biguanide, such as polyhexamethylene biguanide (PHMB). The fabric inner layer material may be substantially a cellulose fiber, preferably substantially rayon, and the fabric outer layer material may be substantially polyester, e.g., a combination of textile matrix grade polyester fiber and amorphous binder grade polyester fiber. The fabric is preferably treated with an aqueous solution of surfactant and PHMB to have about 1500-3500 ppm of extractable PHMB.

Claims

1. A method of preparing a medical dressing comprising:

forming a layered fabric consisting essentially of

an inner layer of hydrophilic material, and

outer layers of hydrophobic material on both sides of the inner layer; and

impregnating a biguanide antimicrobial agent into the inner layer.

2. The method according to claim 1 wherein the inner layer of hydrophilic material is rayon, and the outer layers of hydrophobic material are a combination of textile matrix grade polyester fiber and amorphous binder grade polyester fiber.

3. The method according to claim 2, wherein impregnating the biguanide antimicrobial agent comprises contacting the layered fabric with a solution having a surfactant and polyhexamethylene biguanide.

4. A method comprising forming a dressing consisting essentially of an inner layer of hydrophilic material, outer layers of hydrophobic material on both sides of the inner layer, and a biguanide antimicrobial agent, wherein the biguanide antimicrobial agent is releasably contained in the inner layer.

5. The method of claim 4, wherein the biguanide antimicrobial agent is polyhexamethylene biguanide.

6. The method of claim 5, wherein at least one outer layer is a combination of textile matrix grade polyester fiber and amorphous binder grade polyester fiber.

7. The method of claim 4, wherein the hydrophilic material is rayon, and the hydrophobic material is a combination of textile matrix grade polyester fiber and amorphous binder grade polyester fiber.

8. A method of preparing a sponge comprising forming layered plies of a substrate consisting essentially of at least one inner layer of hydrophilic material, outer layers of hydrophobic material on both sides of the at least one inner layer, and a biguanide antimicrobial agent releasably contained in the inner layer.

9. The method of claim 8, wherein the biguanide antimicrobial agent is polyhexamethylene biguanide.

10. The method of claim 8, further comprising creating a cross-shaped incision at the center of the layered plies.