Ketone measurement system and related method with accuracy and reporting enhancement features

• US 9,486,169 B1
• Filed: 04/20/2015
• Issued: 11/08/2016
• Est. Priority Date: 04/18/2014
• Status: Expired due to Fees

• Current Assignee: Invoy Holdings, Inc.
• Original Assignee: Invoy Technologies, LLC
• Inventors: Ahmad, Lubna M.
• Primary Examiner(s): Lin, Jerry
• Application Number:
  US14/690,756
• Time in Patent Office: 568 Days
• Field of Search: 702/19
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/082 Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath A61B5/083, A61B5/091 take precedence
• CPC Class Codes: A61B 5/097 Devices for facilitating collection of breath or for directing breath into or through measuring devices
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/150358 Strips for collecting blood, e.g. absorbent optical reagent test strips G01N21/8483; chemical reagent test strips G01N33/4875, G01N33/52
• CPC Class Codes: A61B 5/150412 Pointed piercing elements, e.g. needles, lancets for piercing the skin blade-like piercing elements A61B5/150442
• CPC Class Codes: A61B 5/4866 Evaluating metabolism A61B5/083 takes precedence
• CPC Class Codes: A61B 5/6898 Portable consumer electronic devices, e.g. music players, telephones, tablet computers
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence
• CPC Class Codes: G01N 33/49 Blood chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80
• CPC Class Codes: G01N 33/497 of gaseous biological material, e.g. breath
• CPC Class Codes: G01N 33/64 involving ketones

Abstract

A portable ketone measurement device measures ketone levels in breath samples or other bodily fluid samples of a user, and communicates the ketone measurements to an application that runs on a smartphone or other mobile device of the user. The application may communicate with, and report the measurements to, a remote server. One or more components of the system (e.g., the portable ketone measurement device, the mobile application, and/or the server) may, where appropriate, adjust the ketone measurements to compensate for ketone variations resulting from, e.g., the age of the user, a medical condition of the user, a missed medication event, or an interrupted sleep event. The application may, in some scenarios, withhold the display of a ketone measurement from the user until an authorization has been received from the server.

Claims

1. A system for measuring a ketone in a breath of a user, the system comprising:

a portable ketone measurement device that measures the ketone at a first location and generates a measurement signal indicative of the concentration of the ketone in a breath sample of the user, the portable ketone measurement device comprising a pump that moves the breath sample along a flow path to a ketone sensor, and comprising a wireless transceiver capable of wirelessly transmitting the measurement signal;

a communications device located at the first location, the communications device configured to receive a wireless transmission of the measurement signal from the portable ketone measurement device, and to transmit the measurement signal; and

a remote system disposed at a second location remote from the first location that receives the measurement signal from the communications device;

at least one of the portable ketone measurement device, the communications device and the remote system comprising at least one processor that processes parameter data and generates a compensation factor for effecting a modification of the measurement signal to compensate for at least one of the following;

(1) an age of the user, (2) a nutritional ketosis condition of the user, (3) a chronic obstructive pulmonary disease (COPD) condition of the user, (4) a missed medication event by the user, (5) an interrupted sleep condition of the user, (6) a diabetic ketoacidosis condition of the user.

2. A system as recited in claim 1, wherein the communications device comprises a smart phone.

3. A system as recited in claim 2, wherein the smart phone comprises a processor that is programmed to process the parameter data to obtain the compensation factor.

4. A system as recited in claim 1, wherein the parameter data comprises user-specific data.

5. A system as recited in claim 4, wherein the user-specific data comprises at least one of lifestyle data, physical data and pathophysiological data.

6. A system as recited in claim 1, wherein the remote system comprises storage that pre-stores a portion of the parameter data.

7. A system as recited in claim 6, wherein the remote system storage pre-stores the portion of the parameter data in the form of population data.

8. A system as recited in claim 1, wherein the portable ketone measurement device automatically transmits the measurement signal to the communications device upon generation of the measurement signal.

9. A system as recited in claim 1, wherein the communications device automatically transmits the measurement signal to the remote system upon receiving the measurement signal from the portable ketone measurement device.

10. A system as recited in claim 1, wherein the portable ketone measurement device comprises a breath input port configured to connect to a breath sample container.

11. A system as recited in claim 1, wherein the compensation factor is generated based on an age of the user.

12. A method of generating ketone measurements, comprising:

generating, by a portable ketone measurement device, ketone measurements from bodily fluid samples of a user, each ketone measurement generated by the portable ketone measurement device from a respective bodily fluid sample of the user by analyzing the bodily fluid sample with a ketone sensor, the portable ketone measurement device configured to receive an insert-able component containing a bodily fluid sample; and

by execution of program code by one or more processors;

recording, in connection with some, but not all, of the ketone measurements, occurrences of a user condition that can affect ketone measurements;

determining, by analyzing the ketone measurements in conjunction with the recorded occurrences of the user condition, an amount by which the user condition causes the ketone measurements of the user to vary;

determining that a particular ketone measurement generated with the portable ketone measurement device was generated while the user condition was present; and

modifying the particular ketone measurement based on said amount to compensate for the user condition.

13. The method of claim 12, wherein the user condition is a missed medication condition.

14. The method of claim 12, wherein the user condition is an interrupted sleep condition.

15. The method of claim 12, wherein recording the occurrences of the user condition comprises receiving user input via a software application that runs on a communications device that is separate from the portable ketone measurement device.

16. The method of claim 12, further comprising modifying, based on said amount, a previously-generated ketone measurement that was generated prior to determining the amount by which the condition causes the ketone measurements to vary, the previously-generated ketone measurement generated while the user condition was present.

17. The method of claim 12, wherein the one or more processors are separate from the portable ketone measurement device.

18. The method of claim 12, wherein the insert-able component is a breath container.

19. The method of claim 12, wherein the insert-able component is a test strip.

20. A ketone measurement system, comprising:

a portable ketone measurement device configured to generate ketone measurements from bodily fluid samples of a user, the portable ketone measurement device comprising an input port that receives an insert-able component containing a bodily fluid sample, and comprising a ketone sensor that analyzes the bodily fluid samples, the portable ketone measurement device additionally comprising a transceiver capable of communicating the ketone measurements to a communications device associated with the user; and

executable program code that directs a computing device to adjust at least some of the ketone measurements to compensate for a ketone level variation associated with at least one of the following;

(1) an age of the user, (2) a nutritional condition of the user, (3) a pulmonary condition of the user, (4) a missed medication event by the user, (5) an interrupted sleep condition of the user, (6) a diabetic ketoacidosis condition of the user.

21. The ketone measurement system of claim 20, wherein the program code directs the computing device to adjust at least some of the ketone measurements to compensate for a ketone level variation associated with an age of the user.

22. The ketone measurement system of claim 20, wherein the program code directs the computing device to adjust at least some of the ketone measurements to compensate for a ketone level variation associated with a nutritional condition of the user.

23. The ketone measurement system of claim 20, wherein the program code directs the computing device to adjust at least some of the ketone measurements to compensate for a ketone level variation associated with a pulmonary condition of the user.

24. The ketone measurement system of claim 20, wherein the program code directs the computing device to adjust at least some of the ketone measurements to compensate for a ketone level variation associated with a missed medication event of the user.

25. The ketone measurement system of claim 24, further comprising executable program code that directs a computing device to learn an amount of the ketone level variation by analyzing ketone measurements of the user, including both (1) ketone measurements associated with missed medication events, and (2) ketone measurements not associated with a missed medication event.

26. The ketone measurement system of claim 20, wherein the program code directs the computing device to adjust at least some of the ketone measurements to compensate for a ketone level variation associated with an interrupted sleep condition of the user.

27. The ketone measurement system of claim 26, further comprising executable program code that directs a computing device to learn an amount of the ketone level variation by analyzing ketone measurements of the user, including both (1) ketone measurements associated with sleep interruption events, and (2) ketone measurements not associated with a sleep interruption event.

28. The ketone measurement system of claim 20, wherein the program code directs the computing device to adjust at least some of the ketone measurements to compensate for a ketone level variation associated with a diabetic ketoacidosis condition of the user.

29. The ketone measurement system of claim 20, wherein the executable program code comprises code of an application that runs on the communications device associated with the user.

30. The ketone measurement system of claim 20, wherein the executable program code runs on the portable ketone measurement device.

31. The ketone measurement system of claim 20, wherein the executable program code runs on a server that receives the ketone measurements from the communications device associated with the user.

32. The ketone measurement system of claim 20, wherein the insert-able component is a breath container.

33. The ketone measurement system of claim 32, wherein the portable ketone measurement device comprises a pump configured to pump a breath sample from the breath container along a fluid path to the ketone sensor.

34. The ketone measurement system of claim 20, wherein the insert-able component is a test strip.

35. A device-implemented method, comprising:

by a portable ketone measurement device, generating a ketone measurement based on a bodily fluid sample of a user, and wirelessly transmitting the ketone measurement to a mobile communications device associated with the user, wherein generating the ketone measurement comprises obtaining the bodily fluid sample from a fluid sample component that inserts into the portable ketone measurement device, and analyzing the bodily fluid sample with a ketone sensor; and

by the mobile communications device, automatically transmitting the ketone measurement to a remote computer system while withholding the ketone measurement from the user, and subsequently outputting the ketone measurement to the user in response to receiving an authorization from the remote computer system.

36. The device-implemented method of claim 35, further comprising, by the portable ketone measurement device, the mobile communications device, or the remote computer system, adjusting the ketone measurement to compensate for at least one of the following:

(1) an age of the user, (2) a nutritional ketosis condition of the user, (3) a chronic obstructive pulmonary disease (COPD) condition of the user, (4) a missed medication event by the user, (5) an interrupted sleep condition of the user, (6) a diabetic ketoacidosis condition of the user.

37. The device-implemented method of claim 35, wherein the bodily fluid sample is a breath sample obtained from a breath container.