Immunogenic composition

  • US 9,486,515 B2
  • Filed: 06/23/2006
  • Issued: 11/08/2016
  • Est. Priority Date: 06/27/2005
  • Status: Active Grant
First Claim
Patent Images

1. An immunogenic composition comprising(a) N. meningitidis serogroup A capsular saccharide conjugated to a linker by 1-cyano-4-dimethylamino pyridinium tetrafluoroborate chemistry, wherein the linker is conjugated to tetanus toxoid carrier protein by carbodiimide chemistry;

  • (b) N. meningitidis serogroup C capsular saccharide conjugated to a linker by 1-cyano-4-dimethylamino pyridinium tetrafluoroborate chemistry, wherein the linker is conjugated to tetanus toxoid carrier protein by carbodiimide chemistry;

    (c) N. meningitidis serogroup W capsular saccharide directly conjugated to tetanus toxoid carrier protein by 1-cyano-4-dimethylamino pyridinium tetrafluoroborate chemistry; and

    (d) N. meningitides serogroup Y capsular saccharide directly conjugated to tetanus toxoid carrier protein by 1-cyano-4-dimethylamino pyridinium tetrafluoroborate chemistry.

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