Trajectory-based deep-brain stereotactic transcranial magnetic stimulation

• US 9,486,639 B2
• Filed: 09/22/2011
• Issued: 11/08/2016
• Est. Priority Date: 05/05/2006
• Status: Active Grant

• Current Assignee: US Department of Veterans Affairs (Government of the United States of America), Board of Trustees of the Leland Stanford Junior University (Stanford Management Co.)
• Original Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford Management Co.)
• Inventors: Mishelevich, David J., Schneider, M. Bret
• Primary Examiner(s): MATTHEWS, CHRISTINE HOPKINS
• Application Number:
  US13/240,060
• Publication Number:
  US 20120016177A1
• Time in Patent Office: 1,874 Days
• Field of Search: 600 9- 15, 607/2, 607/3
• US Class Current: 1/1
• CPC Class Codes: A61N 2/004 specially adapted for a specific therapy
• CPC Class Codes: A61N 2/006 for magnetic stimulation of nerve tissue
• CPC Class Codes: A61N 2/008 for pain treatment or analgesia
• CPC Class Codes: A61N 2/02 using magnetic fields produced by coils, including single turn loops or electromagnets A61N2/12 takes precedence

Abstract

The present invention provides for Stereotactic Transcranial Magnetic Stimulation (sTMS) at predetermined locations with the brain or spinal cord and incorporates an array of electromagnets arranged in a specified configuration where selected coils in the array are pulsed simultaneously. Activation of foci demonstrated by functional MRI or other imaging techniques can be used to locate the neural region affected. Imaging techniques can also be utilized to determine the location of the designated targets.

Claims

1. A method for applying magnetic field stimulation to a deep brain target, the method comprising the steps of:

positioning a plurality of bent electromagnetic coils at different locations about a subject'"'"'s head, each coil comprising a plurality of concentric loops arranged about a normal axis, the concentric loops of each of the electromagnetic coils having a curved shape relative to a plane that is perpendicular to the normal axis such that the plurality of electromagnetic coils conform to the subject'"'"'s head;

energizing the electromagnetic coils to produce a plurality of magnetic fields, wherein the coils are positioned such that a normal component of each of the magnetic fields points toward a common convergence point, the common convergence point spaced a distance away from the deep brain target and having a predetermined spatial relationship to the deep brain target; and

stimulating the deep brain target by summing stimulation from each of the magnetic fields at the deep brain target, wherein the deep brain target is deeper in the brain and further from the electromagnets than more superficial cortical non-target brain regions between the deep brain target and the electromagnetic coils.

2. The method of claim 1, wherein each electromagnetic coil includes at least two loops.

3. The method of claim 1, wherein energizing the electromagnetic coils comprises energizing the electromagnetic coils at different patterns, frequencies, or patterns and frequencies of stimulation.

4. The method of claim 1, wherein positioning comprises placing the subject'"'"'s head within a frame holding the plurality of electromagnetic coils.

5. The method of claim 1, wherein the plurality of electromagnetic coils are directly adjacent to one another.

6. The method of claim 5, wherein the plurality of electromagnetic coils are not concentric with one another.

7. The method of claim 5, wherein the plurality of electromagnetic coils do not overlap with one another.

8. The method of claim 5, wherein the plurality of electromagnetic coils are attached to one another.

9. The method of claim 5, wherein the plurality of electromagnetic coils are electrically discrete from one another.