Integrated self-contained recorder of biological data for small animal research

• US 9,492,085 B2
• Filed: 03/22/2012
• Issued: 11/15/2016
• Est. Priority Date: 04/12/2006
• Status: Active Grant

• Current Assignee: Alexei L. Vyssotski, Dmitri L. Vyssotski
• Original Assignee: Alexei L. Vyssotski, Dmitri L. Vyssotski
• Inventors: Vyssotski, Alexei L., Vyssotski, Dmitri L.
• Primary Examiner(s): LEVICKY, WILLIAM J
• Application Number:
  US13/427,441
• Publication Number:
  US 20120179386A1
• Time in Patent Office: 1,699 Days
• Field of Search: 600/508, 600/509, 600/529, 600/536
• US Class Current: 1/1
• CPC Class Codes: A61B 2560/0431 Portable apparatus, e.g. comprising a handle or case
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W

Abstract

An apparatus and method for the recording of physiological variables in small animals are described. The apparatus is an integrated self-contained recorder including a converter of biological signals into a digital form, a data storage unit, a data output for transporting the stored data from the recorder after the end of recording session, a power source and an electrical connector arranged for connection of the recorder with at least one sensor of biological signal and mechanical fixation of the recorder at the head of an animal. The recorder may contain a sensor, which receives signals from an external source for synchronization of the stored data with external equipment or observed/registered animal behavior.

Claims

1. A system for recording biological data from a small animal, comprising:

external stationary scientific equipment having an external stationary sensor and an emitter, wherein the external stationary sensor registers animal behavior information of a small animal bearing a recorder;

the emitter of the external stationary scientific equipment transmits the registered animal behavior information to the recorder of the same small animal bearing the recorder,

the recorder comprising;

a biological signal sensor configured to sense at least one biological signal from a small animal;

a convertor configured to convert the at least one biological signal to digital data;

a sensor configured to receive the animal behavior information sent from the emitter of the external stationary scientific equipment and to synchronize the animal behavior information with the digital data locally at the recorder;

a data storage unit integrated to the recorder and configured to store the digital data synchronized with the animal behavior information received from the emitter of the external stationary scientific equipment locally at the recorder;

a data output configured for transporting the stored digital data from the recorder after a recording session; and

,

a power source.

2. The system of claim 1, wherein the biological signal comprises electrical brain activity.

3. The system of claim 1, wherein the sensor configured to receive the animal behavior information from the external stationary scientific equipment is a wireless receiver.

4. The system of claim 3, wherein the sensor configured to receive the information from the external stationary scientific equipment is an acoustic sensor or an optical sensor.

5. The system of claim 4, wherein the optical sensor is an infrared sensor.

6. The system of claim 3, wherein the wireless receiver is a radio wave receiver.

7. The system of claim 1, wherein the recorder is separate from the external stationary scientific equipment.

8. The system of claim 1, wherein the recorder is wireless with respect to the external stationary scientific equipment.

9. The system of claim 1, wherein the external stationary sensor is configured to register an action of the small animal, bearing the recorder.

10. The system of claim 1, wherein the external stationary sensor is configured to register a pressing of the small animal, bearing the recorder, on a lever or a crossing of an infrared beam.

11. The system of claim 1, wherein the external stationary scientific equipment connects with a computer for processing the animal behavior information obtained from the small animal, bearing the recorder and the computer sends the animal behavior information to the recorder through the external stationary emitter.

12. The system of claim 1, wherein the stationary sensor is a video camera.

13. The system of claim 11, wherein the computer is configured to analyze the animal behavior information obtained from the small animal, bearing the recorder, split the animal behavior information into behavioral episodes, classify the behavioral episodes, and send labels of the behavioral episodes to the recorder by the external stationary emitter.

14. The system of claim 1, wherein the external stationary scientific equipment is configured to acquire the animal behavior information from the small animal, bearing the recorder, wherein the external stationary scientific equipment configured to send the animal behavior information obtained from the small animal, bearing the recorder, to the recorder, and the data storage unit configured to store the animal behavior information obtained from the external stationary scientific equipment and acquired by the external stationary scientific equipment from the small animal, bearing the recorder.

15. The system according to claim 1, wherein the external stationary scientific equipment is configured to store the animal behavior information obtained from the small animal, bearing the recorder, prior to sending it to the recorder.

16. The system according to claim 1, wherein a computer receives the animal behavior information from a video camera, and the emitter sends the animal behavior information to the recorder.

17. The system according to claim 1, wherein the external stationary sensor is a video camera that records the animal behavior information, and the video camera connects with a computer.

18. A method of measuring physiological variables in a small animal, comprising:

providing external stationary scientific equipment having an external stationary sensor and an emitter, wherein the external stationary sensor registers animal behavior information of a small animal bearing a recorder, and the emitter of the external stationary scientific equipment transmits the registered animal behavior information to the recorder of the same small animal bearing the recorder,

providing the recorder comprising;

a biological signal sensor configured to sense at least one biological signal from the small animal;

a converter configured to convert the at least one biological signal to digital data;

a sensor configured to receive information sent from external stationary scientific equipment and to synchronize the information with the digital data locally at the recorder;

a data storage unit integrated to the recorder and configured to store the digital data synchronized with the information received from the external stationary scientific equipment locally at the recorder;

a data output configured for transporting stored data from the recorder after a recording session, and a power source;

fixing the recorder to the small animal;

registering the animal behavior information by the external stationary sensor of the external stationary scientific equipment;

sending the animal behavior information from the emitter of the external stationary scientific equipment to the recorder;

acquiring the at least one biological signal from the small animal via the biological signal sensor;

converting the at least one biological signal to the digital data;

receiving the animal behavior information from the external stationary scientific equipment locally at the recorder; and

,

synchronizing the animal behavior information with the digital data locally at the recorder.

19. The method of claim 18, wherein the animal behavior information from the external stationary scientific equipment is transmitted to the recorder wirelessly.

20. The method of claim 18, wherein the animal behavior information from the external stationary scientific equipment is set by an action of the small animal, bearing the recorder.

21. The method of claim 20, wherein the action of the small animal, bearing the recorder, is a pressing on a lever or is a crossing of an infrared beam.

22. The method of claim 18, wherein a computer receives the animal behavior information, analyzes the animal behavior information, splits the animal behavior information into behavioral episodes, classifies the behavioral episodes, and sends labels of the behavioral episodes to the recorder via the emitter.

23. The method according to claim 18, further comprising storing the animal behavior information obtained from the small animal, bearing the recorder, at the external stationary scientific equipment prior to sending it to the recorder.

24. A system for recording biological data from a small animal, comprising:

external stationary scientific equipment having a user interface and an emitter, wherein animal behavior information is obtained from a small animal bearing a recorder and inputted by an operator or an observer into the user interface of the external stationary scientific equipment, and the emitter of the external stationary scientific equipment transmits the inputted animal behavior information to the recorder of the same small animal bearing the recorder,

the recorder comprising;

a biological signal sensor configured to sense at least one biological signal from a small animal;

a convertor configured to convert the at least one biological signal to digital data;

a sensor configured to receive the animal behavior information inputted into the user interface and sent from the emitter of the external stationary scientific equipment and to synchronize the animal behavior information with the digital data locally at the recorder;

a data storage unit integrated to the recorder and configured to store the digital data synchronized with the animal behavior information received from the emitter of the external stationary scientific equipment locally at the recorder;

a data output configured for transporting the stored digital data from the recorder after a recording session; and

,

a power source.

25. The system of claim 24, wherein the operator or observer analyzes the animal behavior information obtained from the small animal, bearing the recorder, splits the animal behavior information into behavioral episodes, classifies the behavioral episodes, and sends labels of the behavioral episodes to the recorder by the external stationary emitter, wherein the labels are stored in the recorder.

26. A system for recording biological data from a small animal, comprising:

external stationary scientific equipment having an external stationary stimulator to provide stimulation to a small animal bearing a recorder and an emitter, and the emitter of the external stationary scientific equipment transmits animal stimulation information to the recorder of the same small animal bearing the recorder,

the recorder comprising;

a biological signal sensor configured to sense at least one biological signal from a small animal;

a convertor configured to convert the at least one biological signal to digital data;

a sensor configured to receive the animal stimulation information sent from the emitter of the external stationary scientific equipment and to synchronize the animal stimulation information with the digital data locally at the recorder;

a data storage unit integrated to the recorder and configured to store the digital data synchronized with the animal stimulation information received from the emitter of the external stationary scientific equipment locally at the recorder;

a data output configured for transporting the stored digital data from the recorder after a recording session; and

,

a power source.

27. The system of claim 26, wherein the emitter is configured to send the animal stimulation information to the recorder simultaneously with the stimulation provided to the small animal, bearing the recorder, by the external stationary stimulator.

28. The system of claim 26, wherein the external stationary stimulator is configured to provide a light stimulation, a sound stimulation, or an electric stimulation.

29. The system of claim 28, wherein a grid floor supplies the electric stimulation to the small animal, bearing the recorder.

30. The system for recording biological data from a small animal according to claim 26, wherein the external stationary scientific equipment is configured to store the animal stimulation information prior to sending it to the recorder.