Tamper resistant dosage forms

  • US 9,492,391 B2
  • Filed: 06/03/2015
  • Issued: 11/15/2016
  • Est. Priority Date: 08/25/2006
  • Status: Active Grant
First Claim
Patent Images

1. A method of treating pain comprising administering to a patient in need thereof a pharmaceutical tablet comprising:

  • (1) at least a first compression shaped and then air cured matrix, wherein said curing is without compression, by heated air having a temperature of at least about 62°

    C. for a duration of at least about 5 minutes, said matrix comprising an opioid or a pharmaceutically acceptable salt thereof in combination with at least one high molecular weight polyethylene oxide having, based on rheological measurements, an approximate molecular weight selected from the group consisting of 4,000,000, 7,000,000, and a combination thereof, and optionally further comprising at least one low molecular weight polyethylene oxide having, based on rheological measurements, an approximate molecular weight of less than 1,000,000;

    (2) optionally a second air cured matrix comprising an opioid or a pharmaceutically acceptable salt thereof in combination with at least one low molecular weight polyethylene oxide having, based on rheological measurements, an approximate molecular weight of less than 1,000,000; and

    (3) optionally a coating,wherein, in said tablet;

    said high molecular weight polyethylene oxide is at least 54% by weight of the total weight of said uncoated tablet;

    said low molecular weight polyethylene oxide, if present, is at least 10% by weight of the total weight of said uncoated tablet; and

    said tablet provides a once-daily or twice-daily extended release tablet of said opioid or pharmaceutically acceptable salt thereof from said tablet.

View all claims
    ×
    ×

    Thank you for your feedback

    ×
    ×