Absorbable, permeability-modulated barrier composites and applications thereof
First Claim
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1. An absorbable, permeability-modulated barrier composite comprising:
- at least three physicochemically distinct components;
one component comprising a flexible film having a thickness of less than 200 microns, the film comprising a synthetic absorbable polymer, a second component comprising a knitted mesh and a third component comprising an electrostatically spun, non-woven microfibrous fabric, and wherein the flexible film is adjoined directly to the knitted mesh which is adjoined directly to the microfibrous fabric to form a three component layered composite;
wherein the knitted mesh comprises an absorbable block copolymer comprising a block derived only from trimethylene carbonate and terminal segments derived from glycolide; and
wherein the flexible film is made of a polyaxial copolyester derived from at least two monomers selected from the group consisting of glycolide, l-lactide, ε
-caprolactone, trimethylene carbonate, p-dioxanone, 1,5-dioxepan-2-one, and a morpholinedione.
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Abstract
Absorbable barrier composites are designed for modulated gas and water permeability depending on clinical use and are formed of at least two physicochemically distinct components, one of which is a film adjoined to a knitted mesh and/or electrostatically spun, non-woven fabric. Depending on the physicochemical properties of the barrier composite, it can be used in neurological and urinogenital surgical procedures as well as tissue engineering and/or as physical barriers to prevent adhesion formation following several types of surgical procedures.
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10 Claims
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1. An absorbable, permeability-modulated barrier composite comprising:
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at least three physicochemically distinct components; one component comprising a flexible film having a thickness of less than 200 microns, the film comprising a synthetic absorbable polymer, a second component comprising a knitted mesh and a third component comprising an electrostatically spun, non-woven microfibrous fabric, and wherein the flexible film is adjoined directly to the knitted mesh which is adjoined directly to the microfibrous fabric to form a three component layered composite; wherein the knitted mesh comprises an absorbable block copolymer comprising a block derived only from trimethylene carbonate and terminal segments derived from glycolide; and wherein the flexible film is made of a polyaxial copolyester derived from at least two monomers selected from the group consisting of glycolide, l-lactide, ε
-caprolactone, trimethylene carbonate, p-dioxanone, 1,5-dioxepan-2-one, and a morpholinedione. - View Dependent Claims (2, 3, 4, 5, 6)
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7. An absorbable, permeability-modulated barrier composite comprising:
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at least three physicochemically distinct components, the first component comprising a flexible film having a thickness of less than 400 microns, the film comprising a synthetic absorbable polymer, the second component comprising an electrostatically spun, non-woven microfibrous fabric, and the third component comprising a knitted mesh, wherein the flexible film is adjoined directly to the knitted mesh and the microfibrous fabric is adjoined directly to the knitted mesh, such that the flexible film and the microfibrous fabric are indirectly joined to each other with the knitted mesh sandwiched therebetween; wherein the knitted mesh comprises an absorbable copolymer formed from a block derived only from trimethylene carbonate and terminal segments derived from glycolide; and wherein the flexible film is made of a polyaxial copolyester derived from at least two monomers selected from the group consisting of glycolide, l-lactide, ε
-caprolactone, trimethylene carbonate, p-dioxanone, 1,5-dioxepan-2-one, and a morpholinedione. - View Dependent Claims (8, 9, 10)
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Specification