Alkylated cyclodextrin compositions and processes for preparing and using the same

  • US 9,493,582 B2
  • Filed: 02/27/2013
  • Issued: 11/15/2016
  • Est. Priority Date: 02/28/2012
  • Status: Active Grant
First Claim
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1. A process for preparing an alkylated cyclodextrin composition comprising an alkylated cyclodextrin, the process comprising:

  • (a) mixing a cyclodextrin with an alkylating agent to form a reaction milieu comprising an alkylated cyclodextrin, one or more unwanted components, and one or more drug-degrading impurities;

    (b) conducting one or more separations to remove the one or more unwanted components from the reaction milieu to form a partially purified solution comprising the alkylated cyclodextrin and the one or more drug-degrading impurities, wherein the one or more separations are ultrafiltration, diafiltration, centrifugation, extraction, solvent precipitation, or dialysis; and

    (c) treating the partially purified solution with a phosphate-free activated carbon having a residual conductivity of 10 μ

    S or less and producing the alkylated cyclodextrin.

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