Enzymatic biosensors with enhanced activity retention for detection of organic compounds
First Claim
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1. A biosensor for use in measuring a concentration of an organic compound analyte, said biosensor comprising:
- a distal portion;
an optical transducer disposed in the distal portion of said biosensor capable of measuring oxygen concentration in situ;
a biocomponent disposed in the distal portion of said biosensor, said biocomponent immobilized within a hydrogel or polymer matrix, and said biocomponent comprising one or more oxygenases from EC family 1.13 and EC family 1.14 for carrying out an oxidation of the organic compound analyte.
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Abstract
Enzymatic biosensors and methods of producing distal tips for biosensor transducers for use in detecting one or more analytes selected from organic compounds susceptible to dehalogenation, organic compounds susceptible to oxygenation and organophosphate compounds susceptible to hydrolysis are disclosed herein, as well as biosensor arrays, methods of detecting and quantifying analytes within a mixture, and devices and methods for delivering reagents to enzymes disposed within the distal tip of a biosensor.
69 Citations
21 Claims
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1. A biosensor for use in measuring a concentration of an organic compound analyte, said biosensor comprising:
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a distal portion; an optical transducer disposed in the distal portion of said biosensor capable of measuring oxygen concentration in situ; a biocomponent disposed in the distal portion of said biosensor, said biocomponent immobilized within a hydrogel or polymer matrix, and said biocomponent comprising one or more oxygenases from EC family 1.13 and EC family 1.14 for carrying out an oxidation of the organic compound analyte. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification