Optimization of alginate encapsulation of islets for transplantation
First Claim
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1. A method for controlling the blood glucose levels in a subject in need thereof, comprising:
- a. providing an implantable device having pancreatic islets containing insulin-producing cells in an amount sufficient to maintain blood glucose levels at a normal level in the subject, macroencapsulated in a three dimensional hydrogel, wherein the three dimensional hydrogel has a planar configuration and has a thickness from 300 microns to 500 microns wherein the amount sufficient to maintain blood glucose levels at a normal level in the subject is a density from 27,000 islets/cm3 to 43,750 islets/cm3; and
b. implanting the implantable device in the subject,wherein following implantation, the implantable device maintains blood glucose levels at a normal level in the subject for at least 20 days.
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Abstract
Apparatus is provided, including a plurality of islets, and a hydrogel configured to macroencapsulate the plurality of islets. The hydrogel is implantable in a subcapsular space (21) of a kidney (22) of a subject and is shaped to define a planar configuration. Other applications are also described.
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16 Claims
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1. A method for controlling the blood glucose levels in a subject in need thereof, comprising:
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a. providing an implantable device having pancreatic islets containing insulin-producing cells in an amount sufficient to maintain blood glucose levels at a normal level in the subject, macroencapsulated in a three dimensional hydrogel, wherein the three dimensional hydrogel has a planar configuration and has a thickness from 300 microns to 500 microns wherein the amount sufficient to maintain blood glucose levels at a normal level in the subject is a density from 27,000 islets/cm3 to 43,750 islets/cm3; and b. implanting the implantable device in the subject, wherein following implantation, the implantable device maintains blood glucose levels at a normal level in the subject for at least 20 days. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification