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Optimization of alginate encapsulation of islets for transplantation

  • US 9,540,630 B2
  • Filed: 09/16/2009
  • Issued: 01/10/2017
  • Est. Priority Date: 09/17/2008
  • Status: Active Grant
First Claim
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1. A method for controlling the blood glucose levels in a subject in need thereof, comprising:

  • a. providing an implantable device having pancreatic islets containing insulin-producing cells in an amount sufficient to maintain blood glucose levels at a normal level in the subject, macroencapsulated in a three dimensional hydrogel, wherein the three dimensional hydrogel has a planar configuration and has a thickness from 300 microns to 500 microns wherein the amount sufficient to maintain blood glucose levels at a normal level in the subject is a density from 27,000 islets/cm3 to 43,750 islets/cm3; and

    b. implanting the implantable device in the subject,wherein following implantation, the implantable device maintains blood glucose levels at a normal level in the subject for at least 20 days.

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