Methods of colchicine administration

  • US 9,555,029 B2
  • Filed: 12/11/2014
  • Issued: 01/31/2017
  • Est. Priority Date: 08/20/2013
  • Status: Active Grant
First Claim
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1. A method of treating a patient for an inflammatory disorder, wherein the inflammatory disorder is chronic gout, familial Mediterranean fever or Behcet'"'"'s disease, with colchicine while concomitantly administering a second drug that is not an inhibitor of the cytochrome P450 3A4 isoenzyme (CYP3A4) but is an inhibitor of P-glycoprotein 1 (P-gp), wherein the second drug is propafenone, wherein the method comprises:

  • a) administering to the patient a therapeutically effective fixed maintenance dose of colchicine in an amount of from about 0.6 to about 1.2 mg/day, for a maintenance period of a plurality of days, without administering propafenone;

    b) after step (a), administering to the patient one or more therapeutically effective doses of propafenone; and

    c) concomitantly with step (b), administering to the patient the fixed maintenance dose of colchicine of step (a) without dose reduction.

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