Method and system for determining analyte levels

• US 9,558,325 B2
• Filed: 06/24/2013
• Issued: 01/31/2017
• Est. Priority Date: 05/14/2007
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Hayter, Gary Alan, Budiman, Erwin Satrya
• Primary Examiner(s): Brusca, John S
• Application Number:
  US13/925,685
• Publication Number:
  US 20130282403A1
• Time in Patent Office: 1,317 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 2560/0242 adapted to measure environmental factors, e.g. temperature, pollution
• CPC Class Codes: A61B 2560/0252 using ambient temperature
• CPC Class Codes: A61B 5/002 Monitoring the patient using a local or closed circuit, e.g. in a room or building A61B5/0017 takes precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6849 in combination with a needle set
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 40/67 for remote operation

Abstract

Methods and apparatus for analyte level estimation are provided for filtering measurement data. In an embodiment, a present predicted analyte level estimate is determined. A present corrected analyte level estimate is determined based at least in part on the determined present predicted analyte level estimate and a received present monitored analyte measurement data. One or more of the medication infusion rate or the received present monitored analyte measurement data are filtered using a rate variance filter, wherein when the medication infusion rate exceeds a predetermined threshold level, the rate variance filter is adjusted from a predetermined setting to a modified setting to be responsive to changes in the present monitored analyte measurement data after a predetermined time period lapses.

Claims

1. A method implemented using one or more processors, comprising:

determining a present predicted analyte level estimate based at least in part on a medication infusion rate and a past predicted analyte level estimate;

determining a present corrected analyte level estimate based at least in part on the determined present predicted analyte level estimate and a received present monitored analyte measurement data; and

filtering, using a rate variance filter, one or more of the medication infusion rate or the received present monitored analyte measurement data;

wherein when the medication infusion rate exceeds a predetermined threshold level, adjusting the rate variance filter from a predetermined setting to a modified setting to be responsive to changes in the present monitored analyte measurement data after a predetermined time period lapses.

2. The method of claim 1, further including receiving one or more external parameters, wherein determining the present predicted analyte level estimate is based at least in part on the received one or more external parameters.

3. The method of claim 2, wherein the one or more external parameters includes one or more of a calorie intake amount, a level of physical exertion, or a carbohydrate amount.

4. The method of claim 1, wherein filtering includes using a Kalman filter.

5. The method of claim 1, wherein the predetermined time period is measured from a time when the medication infusion rate exceeds the predetermined threshold level.

6. The method of claim 1, further including reporting the filtered received present monitored analyte measurement data, wherein reporting includes displaying the filtered received present monitored analyte measurement data.

7. An apparatus, comprising:

one or more processing units; and

a memory operatively coupled to the one or more processing units, the memory for storing instructions which, when executed by the one or more processing units, causes the one or more processing units to determine a present predicted analyte level estimate based at least in part on a medication infusion rate and a past predicted analyte level estimate, to determine a present corrected analyte level estimate based at least in part on the determined present predicted analyte level estimate and a received present monitored analyte measurement data, and to filter, using a rate variance filter, one or more of the medication infusion rate or the received present monitored analyte measurement data, wherein when the medication infusion rate exceeds a predetermined threshold level, the one or more processing units are configured to adjust the rate variance filter from a predetermined setting to a modified setting to be responsive to changes in the present monitored analyte measurement data after a first predetermined time period lapses.

8. The apparatus of claim 7, wherein the memory includes instructions to receive one or more external parameters, and to determine the present predicted analyte level estimate based at least in part on the received one or more external parameters.

9. The apparatus of claim 8, wherein the one or more external parameters includes one or more of a calorie intake amount, a level of physical exertion, or a carbohydrate amount.

10. The apparatus of claim 8, wherein when the one or more external parameters exceeds a predetermined threshold level, the rate variance filter is adjusted from the predetermined setting to the modified setting to be more responsive to changes in the present monitored analyte measurement data after a first predetermined time period lapses.

11. The apparatus of claim 10, wherein the first predetermined time period is measured from the time the one or more external parameters exceeds the predetermined threshold level.

12. The apparatus of claim 7, wherein the first predetermined time period is measured from a time when the medication infusion rate exceeds the predetermined threshold level.

13. The apparatus of claim 7, wherein the rate variance filter is adjusted to the predetermined setting after a second predetermined time period lapses, wherein the second predetermined time period is greater than the first predetermined time period.

14. The apparatus of claim 13, wherein the second predetermined time period is measured from a time the medication infusion rate exceeds the predetermined threshold level.

15. A method implemented using one or more processors, comprising:

determining a rate of change of a monitored analyte level;

anticipating a change in a direction of the rate of change of the monitored analyte level based at least in part on a change in characteristic information of a medication delivery device including one or more of a medication delivery rate, a medication delivery amount, or a medication delivery time period;

evaluating received analyte related signals based on the anticipated change in the direction of the rate of change of the monitored analyte level;

determining an estimated monitored analyte level based at least in part on the received analyte related signals; and

filtering, using a rate variance filter, the received analyte related signals based on the determined rate of change of the monitored analyte level to generate filtered analyte related signals;

wherein when the change in the characteristic information of the medication delivery device exceeds a predetermined threshold level, adjusting the rate variance filter from a predetermined setting to a modified setting to be responsive to changes in the monitored analyte level after a first predetermined time period lapses.

16. The method of claim 15, further including reporting the generated filtered analyte related signals.

17. The method of claim 16, wherein reporting the generated filtered analyte related signals includes displaying the generated filtered analyte related signals.

18. The method of claim 15, wherein anticipating the change in the direction of the rate of change of the monitored analyte level occurs within a predetermined time following the change in the characteristic information.

19. The method of claim 15, wherein the first predetermined time period is measured from the time the characteristic information of the medication delivery device exceeds the predetermined threshold level.

20. The method of claim 15, wherein the rate variance filter is adjusted to the predetermined setting after a second predetermined time period lapses, wherein the second predetermined time period is greater than the first predetermined time period, and further wherein the second predetermined time period is measured from the time the medication infusion rate exceeds the predetermined threshold level.