Antimicrobial solutions

• US 9,565,857 B2
• Filed: 09/09/2011
• Issued: 02/14/2017
• Est. Priority Date: 09/10/2010
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Raad, Issam, Abiaad, George
• Primary Examiner(s): Brooks, Clinton
• Assistant Examiner(s): Shiao, Yih-Horng
• Application Number:
  US13/821,546
• Publication Number:
  US 20130231302A1
• Time in Patent Office: 1,985 Days
• Field of Search: 514/635, 514/54, 206/524.1
• US Class Current: 1/1
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/30 characterised by the surfactants
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 31/14 Ethers
• CPC Class Codes: A01N 37/44 containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
• CPC Class Codes: A01N 43/16 with oxygen as the ring hetero atom
• CPC Class Codes: A01N 45/00 Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring halogenated hydrocarbons A01N29/08; condensed with heterocyclic rings A01N43/00
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A61K 31/085 having an ether linkage to aromatic ring nuclear carbon
• CPC Class Codes: A61K 31/155 Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• CPC Class Codes: A61L 2/186 Peroxide solutions
• CPC Class Codes: A61L 2202/24 Medical instruments, e.g. endoscopes, catheters, sharps
• CPC Class Codes: A61L 2300/206 Biguanides, e.g. chlorohexidine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention provides antimicrobial solutions that in certain cases comprise a biguanide and a glycol ether and, in some cases, optionally also includes combinations of at least one an alcohol, at least one chelator, glycerol, deoxycholate, and/or at least one alkylpolyglucoside. In certain aspects the invention comprises a biguanide and deoxycholate or a combination of chelator, ethanol, and alkylpolyglucoside. Also provided are methods for rapidly killing and/or reducing bacteria, fungi, or virus from surfaces, for example, including surfaces of indwelling medical devices and organic surfaces such as skin and sutures, and inorganic surfaces such as medical equipment, pipelines etc.

Claims

1. An antimicrobial composition comprising (a) a biguanide selected from the group consisting of polyhexamethylene biguanide (PHMB), chlorhexidine, alexidine and hexamidine, (b) a dipropylene glycol n-butyl ether, and EDTA 4Na chelator, in respective amounts effective to eradicate a population of methicillin-resistant Staphylococcus aureus using a standard operating procedure (SOP) quantitative germicidal spray test.

2. The composition of claim 1, wherein the composition further an alkylpolyglucoside.

3. The composition of claim 1, wherein the biguanide is chlorhexidine.

4. The composition of claim 1, further comprising an effective amount of deoxycholate.

5. The composition of claim 2, wherein the alkylpolyglucoside is selected from the group consisting of capryl glucoside, decyl glucoside, coco-glucoside, and lauryl glucoside.

6. A method for eradicating drug resistant bacteria on a surface comprising contacting the surface with the composition of claim 1 for at least one minute.

7. The method of claim 6, wherein the composition further comprises an alkylpolyglucoside.

8. The method of claim 6, wherein the biguanide is chlorhexidine.

9. The method of claim 6, further comprising an effective amount of deoxycholate.

10. The method of claim 7, wherein the alkylpolyglucoside is selected from the group consisting of capryl glucoside, decyl glucoside, coco-glucoside, and lauryl glucoside.

11. The method of claim 6, wherein the drug resistant bacteria are selected from the group consisting of MRSA, vancomycin resistant enterobacter (“

VRE”

) and multi-drug resistant P. aeruginosa and Actinetobacter.

12. The method of claim 11, wherein the drug resistant bacteria are MRSA.

13. A kit for disinfecting a surface, wherein the kit comprises the composition of claim 1.

14. The kit of claim 13, wherein the biguanide and the dipropylene glycol n-butyl ether are contained in separate containers.

15. A syringe, comprising a unit dose of a pharmacologically effective amount of a solution comprising the composition of claim 1.

16. The antimicrobial composition of claim 1, wherein the biguanide is PHMB.

17. The method of claim 6, wherein the biguanide is PHMB.

18. The composition of claim 1, wherein the composition does not include at least one alcohol.

19. The method of claim 6, wherein the composition does not include at least one alcohol.

20. The kit of claim 13, wherein the composition does not include at least one alcohol.

21. The syringe of claim 15, wherein the composition does not include at least one alcohol.