Neuro-stimulation

• US 9,566,439 B2
• Filed: 07/19/2010
• Issued: 02/14/2017
• Est. Priority Date: 07/20/2009
• Status: Active Grant

• Current Assignee: Saluda Medical Pty Ltd.
• Original Assignee: Saluda Medical Pty Ltd.
• Inventors: Single, Peter, Robinson, David, Parker, John, Ayre, Peter, Karantonis, Dean
• Primary Examiner(s): Terrell, Emily C
• Application Number:
  US13/383,800
• Publication Number:
  US 20120161945A1
• Time in Patent Office: 2,402 Days
• Field of Search: 340/12.1, 340/539.12, 607/45
• US Class Current: 1/1
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/36146 specified by the stimulation parameters
• CPC Class Codes: A61N 1/36189 using modulation techniques

Abstract

The invention is a distributed implantable neuro-stimulation system, comprising an implant controller including control logic to transmit two time-varying power signals, varying between two levels and out of phase with the other, and a command signal modulated onto at least one of the power signals. One or more electrode cells, each having control logic to extract charge from the power signals and recover commands from the command signal. A two-wire bus interconnecting the implant controller and all the electrode cells, to carry one of the time varying signals in each of the two wires, and to carry the command signal.

Claims

1. A distributed implantable neuro-stimulation system, comprising:

an implant controller including two feed-throughs to provide electrical pathways for a first bus signal and a second bus signal, the implant controller further including control logic to transmit a first time-varying power signal and a second time-varying power signal, the first time-varying power signal and the second time-varying power signal varying between two levels, the first time-varying power signal varying in opposite phase to the second time-varying power signal, the first time-varying power signal forming the first bus signal, the second time-varying power signal forming the second bus signal, and to modulate a command signal onto the first time-varying power signal and the second time-varying power signal;

two or more electrode cells, each electrode cell having two feed-throughs to provide electrical pathways for the first bus signal and the second bus signal;

control logic to extract charge from at least one of the first bus signal and the second bus signal and recover commands from the first bus signal or the second bus signal; and

a two-wire bus having a first wire and a second wire extending from the two feed-throughs of the implant controller to the two feed-throughs of each of the two or more electrode cells interconnecting the implant controller and the two or more electrode cells in parallel to carry on the first wire the first bus signal formed by the first time-varying power signal with the command signal modulated thereon, and to carry on the second wire the second bus signal formed by the second time-varying power signal and the command signal modulated therein.

2. The system according to claim 1, wherein, in operation, when recovered commands select an electrode of at least one of the electrode cells to deliver a stimulus, the control logic within the selected cell uses the commands to control the selected electrode to deliver extracted charge, in cooperation with at least one other electrode.

3. The system according to claim 2, a stimulus is delivered in the form of a biphasic pulse which have an anodic and a cathodic phase, with matched charge in each phase.

4. The system according to claim 3, wherein the control logic of each electrode cell is further operable to recover timing information from at least one of the first bus signal and the second bus signal to coordinate a selected electrode to step through anodic and cathodic phases of the biphasic pulse in cooperation with at least one other electrode.

5. The system according to claim 4, wherein the timing information is in the form of crossovers in at least one of the first bus signal and the second bus signal.

6. The system according to claim 4, wherein the timing information is in the form of crossovers with fixed frequency.

7. The system according to claim 3 wherein the commands define the amplitude of each phase the biphasic pulse and whether the biphasic pulse is cathodic or anodic in the first phase.

8. The system according to claim 1, wherein, in operation, recovered commands select plural electrodes to make telemetry measurements.

9. The system according to claim 8, wherein the selected electrodes make measurements in sequence and deliver telemetry measurements to the implant controller.

10. The system according to claim 1, wherein commands are modulated onto the power signal using phase modulated pulse pairs.

11. The system according to claim 1, wherein the implant controller and electrode cells each comprise a switch to selectively allow the flow of stimulus current from the implant controller to the electrode cell, and vice versa, and to control the direction of stimulus current.

12. The system according to claim 1, wherein the control logic in both the implant controller or electrode cells, or both, are provided by a processor or programmable logic array.

13. The system according to claim 1, wherein at least one of the electrode cells stores commands for more than one stimulation.

14. The system according to claim 1, wherein more than two electrode cells take part in generating a stimulus.

15. An implantable implant controller for delivering neuro-stimulation, including:

two feed-throughs to provide electrical pathways for a first bus signal and a second bus signal; and

control logic to transmit a first time-varying power signal and a second time-varying power signal, the first time-varying power signal and the second time-varying power signal varying between two levels, the first time-varying power signal varying in opposite phase to the second time-varying power signal, the first time-varying power signal forming the first bus signal, the second time-varying power signal forming the second bus signal, and to modulate a command signal onto the first power signal and the second power signal;

wherein, in operation, the implant controller is connectable to plural electrode cells by a two-wire bus having a first wire and a second wire, the first wire operable to carry the first bus signal formed by the first time-varying power signal with the command signal modulated thereon, the second wire operable to carry the second bus signal formed by the second time-varying power signal with the command signal modulated therein, each electrode cell having two feed-throughs to provide electrical pathways for the first bus signal and the second bus signal, each electrode cell having control logic to extract charge from at least one of the first bus signal and the second bus signal and recover commands from the first bus signal or the second bus signal, and the two-wire bus extends from the two feed-throughs of the implant controller to the two feed-throughs of each of the two or more electrode cells.

16. The controller according to claim 15, wherein, in operation, when recovered commands select an electrode of the electrode cell to deliver a stimulus, the control logic within the selected cell uses the commands to control the selected electrode to deliver extracted charge, in cooperation with at least one other electrode.

17. The controller according to claim 15, further comprising a reference electrode and a multi-pole switch to selectively connect the reference electrode to a voltage source, a current source or an open circuit to coordinate delivery of the stimulus.

18. The controller according to claim 15, further comprising control logic and an alternator to deliver the first time-varying power signal and the second time-varying power signal;

and

a clock and data transmitter to modulate at least one of the first time-varying power signal and the second time-varying power signal with clock and data signals.

19. An implantable electrode cell for delivering neuro-stimulation, including:

two feed-throughs to provide electrical pathways for a first bus signal formed by a first time-varying power signal and a second bus signal formed by a second time-varying power signal, the first time-varying power signal and the second time-varying power signal, varying between two levels, the first time-varying power signal being in opposite phase to the second time-varying power signal, and a command signal modulated onto the first time-varying power signal and the second time-varying power signal;

at least one electrode; and

control logic to extract charge from at least one of the first bus signal and the second bus signal to recover commands from the first bus signal or the second bus signal, and to deliver extracted charge to the electrode;

wherein the electrode cell is connectable to an implant controller and at least one other electrode cell by a two-wire bus having a first wire and a second wire, the implant controller having two feed-throughs to provide electrical pathways for the first bus signal and the second bus signal and control logic to form the first bus signal and the second bus signal, the two wire bus operable to carry on the first wire the first bus signal formed by the first time-varying power signal with the command signal modulated therein, to carry on the second wire the second bus signal formed by the second time-varying power signal with the command signal modulated thereon, and extend from the two feed-throughs of the implant controller to the two feed-throughs of the electrode cells.

20. The electrode cell according to claim 19, wherein, in operation, when recovered commands select an electrode of the electrode cell to deliver a stimulus, the control logic within the selected cell uses the commands to control the selected electrode to deliver extracted charge, in cooperation with at least one other electrode.

21. The electrode cell according to claim 20, wherein the stimulus is a biphasic pulse having anodic and cathodic phases.

22. The electrode cell according to claim 21, wherein the control logic is further operable to recover timing information from at least one of the bus signals to coordinate a selected electrode to step through anodic and cathodic phases of the biphasic pulse in cooperation with at least one other electrode.

23. The electrode cell according to claim 22, further comprising a multi-pole switch to selectively connect an electrode to a voltage source, a current source or an open circuit to coordinate delivery of a stimulus.

24. The electrode cell according to claim 23, wherein the control logic in the electrode cell is housed in a chip.

25. The electrode cell according to claim 24, wherein the chip provides a substrate for mounting the following components:

a rectifier and storage capacitor to extract charge from at least one of the first bus signal and the second bus signal;

a clock and data receiver to recover clock and data signals from the first bus signal; and

a current source to deliver extracted charge to an electrode.

26. A method of operating an implantable electrode cell for delivering neuro-stimulation, comprising the steps of:

receiving a first bus signal formed by a first time-varying power signal, and a second bus signal formed by a second time-varying power signal, the first time-varying power signal and the second time-varying power signal varying between two levels, the first time-varying power signal being in opposite phase to the second time-varying power signal, and a command signal modulated onto the first time-varying power signal and the second time-varying power signal;

determining whether the first bus signal is addressed to the electrode cell;

if the electrode cell has more than one electrode, determining which electrode is selected;

directing electrical charge from at least one of the first bus signal and the second bus signal to an on-board current source;

recovering commands from the first bus signal or the second bus signal;

setting the current of the current source to the value defined by the recovered commands,

connecting the electrode to the on-board current source at a first time prescribed by the recovered commands; and

disconnecting the electrode from the current source at a second time prescribed by the recovered commands.

28. The signals according to claim 26, wherein commands are modulated using differential pulse phase modulation.

27. A pair of signals for transmission between an implant controller and an electrode cell, comprising:

a first time-varying power signal, a second time-varying power signal, the first time-varying power signal and the second time-varying power signal varying between two levels the first time-varying power signal being in opposite phase to the second time-varying power signal;

wherein the first time-varying power signal and second time-varying power signal are modulated to represent a command, the command selecting an electrode of at least one of the electrode cells to deliver a stimulus, and

control logic within the selected cell that uses the command modulated onto the first time-varying power signal or the second time-varying power signal to control the selected electrode to deliver charge extracted from at least one of the first time-varying power signal and second time-varying power signal, in cooperation with at least one other electrode.