Controlled release hydrocodone formulations

  • US 9,572,804 B2
  • Filed: 02/09/2016
  • Issued: 02/21/2017
  • Est. Priority Date: 10/30/2000
  • Status: Active Grant
First Claim
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1. A solid oral controlled-release dosage form of hydrocodone, the dosage form comprising a matrix comprising hydrocodone or a pharmaceutically acceptable salt thereof and a cellulose ether, such that the dosage form provides a ratio of a plasma concentration of hydrocodone at the end of a dosing interval to a maximum plasma concentration of hydrocodone during the dosing interval of from 0.55 to 1 and effective pain relief over a period of time of about 12 hours or longer after administration to a human patient, whereinthe dosage form is a tablet, andthe hydrocodone or pharmaceutically acceptable salt thereof is the only active agent in the dosage form.

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