Bicyclic aryl sphingosine 1-phosphate analogs

  • US 9,572,824 B2
  • Filed: 10/05/2015
  • Issued: 02/21/2017
  • Est. Priority Date: 08/05/2009
  • Status: Active Grant
First Claim
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1. A method for treatment of a pathological condition or symptom in a mammal, wherein the pathological condition is multiple sclerosis, an autoimmune disease, a chronic inflammatory disorder, asthma, an inflammatory neuropathy, arthritis, transplantation rejection, Crohn'"'"'s disease, ulcerative colitis, lupus erythematosis, psoriasis, an ischemia-reperfusion injury, a solid tumour, tumour metastasis, a disease associated with angiogenesis, a vascular disease, neuropathic pain, acute viral disease, an inflammatory bowel condition, insulin or non-insulin dependent diabetes, inhibited cell migration, over-proliferation and secretion of effector cytokines, or lack of secretion of the suppressive cytokine IL-10, comprising administering to said mammal an effective amount of a compound of formula (IIa)

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