Process to prepare treprostinil, the active ingredient in remodulin®

  • US 9,593,066 B2
  • Filed: 09/10/2015
  • Issued: 03/14/2017
  • Est. Priority Date: 12/17/2007
  • Status: Active Grant
First Claim
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1. A pharmaceutical composition comprising treprostinil or a pharmaceutically acceptable salt thereof, said composition prepared by a process comprising providing a starting batch of treprostinil having one or more impurities resulting from prior alkylation and hydrolysis steps, forming a salt of treprostinil by combining the starting batch and a base, isolating the treprostinil salt, and preparing a pharmaceutical composition comprising treprostinil or a pharmaceutically acceptable salt thereof from the isolated treprostinil salt, whereby a level of one or more impurities found in the starting batch of treprostinil is lower in the pharmaceutical composition, and wherein said alkylation is alkylation of benzindene triol.

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