Measuring device and glucose concentration measurement method of the measuring device

• US 9,597,020 B2
• Filed: 10/16/2013
• Issued: 03/21/2017
• Est. Priority Date: 10/16/2012
• Status: Active Grant

• Current Assignee: Electronics and Telecommunications Research Institute
• Original Assignee: Electronics and Telecommunications Research Institute
• Inventors: Song, Hyun Woo
• Primary Examiner(s): Chen, Tse
• Assistant Examiner(s): Lee, Yoojin
• Application Number:
  US14/055,713
• Publication Number:
  US 20140107438A1
• Time in Patent Office: 1,252 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 3/1005 for measuring distances inside the eye, e.g. thickness of the cornea A61B3/11 takes precedence
• CPC Class Codes: A61B 3/102 for optical coherence tomography [OCT]
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14558 by polarisation

Abstract

The inventive concept relates to a measuring device. The measuring device irradiates a first beam including a polarization component and a second beam which is a wavelength swept laser having a coherence length previously set and can measure a glucose concentration of an aqueous humor by measuring an optical path length and the rotation amount of a polarization plane respectively from a first output beam and a second output beam being output from an eye.

Claims

1. A method of measuring a glucose concentration of a measuring device comprising:

generating a first beam including polarizing components, which are applied by a polarizer;

generating a second beam which is a wavelength swept laser beam having a coherence length previously set;

sending a mixed beam obtained by mixing the first and second beams to an eye in a first direction;

measuring a net optical path length by interference between a reflection beam which is reflected from a reference reflector and a first output beam being output returning from the eye in a first direction, wherein the measuring the net optical path length comprises;

generating an interference beam by interference between the first output beam and the reflection beam;

measuring an angle of a surface of the lens with respect to an in incident direction using an optical coherence tomography signal included in the interference beam; and

estimating the net optical path length using the angle and at least one of optical path length between reflection surfaces;

measuring the rotation amount of a polarization plane from a second output beam being output in a second direction having a specific angle with respect to the first direction; and

measuring a glucose concentration of an aqueous humor on the basis of the net optical path length and the rotation amount of the polarization plane.

2. The method of measuring a glucose concentration of claim 1, wherein the measuring the rotation amount of a polarization plane comprises:

measuring a change of a polarization component by comparing a polarization component included in the first beam with a polarization component included in the second output beam; and

measuring the rotation amount of the polarization plane through the change of the polarization component.

3. The method of measuring the rotation amount of a polarization plane of claim 2, wherein measuring the change of the polarization component comprises:

applying a linear polarization in the first beam using the polarizer;

measuring a polarization plane of a linear polarization included in the second output beam using an optical activity measurement unit; and

comparing the polarization plane in the second output beam with a polarization plane in the first beam.

4. The method of measuring a glucose concentration of claim 1, wherein the measuring the glucose concentration includes determining a glucose concentration from a look-up table of a glucose concentration on the basis of the net optical path length and the rotation amount of the polarization plane.

5. The method of measuring a glucose concentration of claim 1, further comprising displaying the measured glucose concentration through a display device.

6. The method of measuring a net optical path length of claim 1, wherein measuring the angle of a surface of the lens with respect to an incident direction comprises measuring an optical coherence tomographic image of the lens surface using a scanner.

7. The method of measuring a net optical path length of claim 1, wherein generating the interference beam by interference between the first output beam and the reflection beam comprises:

sending the second beam through a beam output unit to the eye; and

receiving the first output beam returning from the eye through the beam output unit.