Cell construct comprising polymer blocks having biocompatibility and cells
First Claim
1. A cell construct comprising polymer blocks having biocompatibility and cells, wherein the polymer blocks are arranged in spaces between the cells, wherein(i) the polymer blocks have surface irregularities and a non-uniform surface shape, and the polymer blocks are obtained by pulverizing freeze-dried product which comprises the polymer,(ii) the polymer blocks have a size as defined by a sieve of from 20 μ
- m to 150 μ
m,(iii) the ratio between the polymer blocks and the cells is 0.00001 to 0.006 μ
g of the polymer blocks per cell; and
(iv) the thickness or diameter of the cell construct is from 400 μ
m to 3 cm.
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Abstract
It is an object of the present invention to provide a cell three-dimensional construct that has a thickness sufficient for tissue regeneration and comprises cells uniformly distributed therein. The present invention provides a cell construct comprising polymer blocks having biocompatibility and cells, wherein the plural polymer blocks are arranged in spaces between the plural cells.
38 Citations
13 Claims
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1. A cell construct comprising polymer blocks having biocompatibility and cells, wherein the polymer blocks are arranged in spaces between the cells, wherein
(i) the polymer blocks have surface irregularities and a non-uniform surface shape, and the polymer blocks are obtained by pulverizing freeze-dried product which comprises the polymer, (ii) the polymer blocks have a size as defined by a sieve of from 20 μ - m to 150 μ
m,(iii) the ratio between the polymer blocks and the cells is 0.00001 to 0.006 μ
g of the polymer blocks per cell; and(iv) the thickness or diameter of the cell construct is from 400 μ
m to 3 cm. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
- m to 150 μ
Specification