Detecting neurochemical or electrical signals within brain tissue

• US 9,603,522 B2
• Filed: 08/26/2010
• Issued: 03/28/2017
• Est. Priority Date: 08/26/2009
• Status: Active Grant

• Current Assignee: Mayo Foundation For Medical Education And Research (Mayo Clinic), University of Memphis Research Foundation
• Original Assignee: Mayo Foundation For Medical Education And Research (Mayo Clinic), University of Memphis Research Foundation
• Inventors: Lee, Kendall H., Bennet, Kevin E., Blaha, Charles D.
• Primary Examiner(s): NATNITHITHADHA, NAVIN
• Application Number:
  US13/392,387
• Publication Number:
  US 20120165634A1
• Time in Patent Office: 2,406 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/02 Details of sensors specially adapted for in-vivo measurements
• CPC Class Codes: A61B 2562/043 in a linear array
• CPC Class Codes: A61B 5/00 Measuring for diagnostic purposes radiation diagnosis A61B6/00; diagnosis by ultrasonic, sonic or infrasonic waves A61B8/00; Identification of persons
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence
• CPC Class Codes: A61B 5/4082 Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
• CPC Class Codes: A61B 5/6814 Head
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation

Abstract

This document relates to methods and materials involved in detecting neurochemical signals, electrophysiological signals, ions, or combinations thereof with brain tissue. For example, methods and materials for using probes to detect neurochemical signals (e.g., neurotransmitter concentrations), electrical signals, or combinations thereof during deep brain stimulation are provided.

Claims

1. A deep brain stimulation system, comprising:

a probe comprising (i) an electrode configured to apply an electrical stimulus to a region of brain tissue using a fast-scan cyclic voltammetry technique and (ii) a first sensor configured to be located in said region of said brain tissue during application of said electrical stimulus and to generate a signal indicative of a detected level of said neurochemical or said ion present in said region of said brain tissue, and

a control unit in communication with said probe, wherein said control unit is configured to receive information from said probe about said detected level of said neurochemical or said ion and is configured to send information to said probe about a level or a timing of electrical stimulus to apply to said region of said brain tissue,

wherein said probe comprises two or more sensors including the first sensor, wherein one of said two or more sensors is configured to detect a first neurochemical or ion, wherein another of said two or more sensors is configured to detect a second neurochemical or ion.

2. The deep brain stimulation system of claim 1, wherein said first sensor is configured to detect a neurochemical selected from the group consisting of dopamine, serotonin, adenosine, adenine mono- or tri-phosphate, norepinephrine, GABA, histamine, acetylcholine, glutamate, aspartate, epinephrine, nitric oxide, glycine, tryptamine, phenylethylamine, tyramine, and octopamine.

3. The deep brain stimulation system of claim 1, wherein said first sensor is configured to detect an ion selected from the group consisting of calcium, magnesium, sodium, potassium, protons, iron, copper, chromium, lead, mercury, cobalt, gold, lithium, cesium, barium, zinc, chloride, bicarbonate, phosphate, bromide, iodide, sulfide, oxide, sulfide, and fluoride.

4. The deep brain stimulation system of claim 1, wherein said two or more sensors are respectively configured to detect two or more of dopamine, serotonin, adenosine, norephinephrine, GABA, histamine, acetylcholine, or glutamate.

5. The deep brain stimulation system of claim 1, wherein said probe comprises a second sensor that is configured to detect electrical brain signals.

6. The deep brain stimulation system of claim 1, wherein said probe and said control unit are physically connected.

7. The deep brain stimulation system of claim 1, wherein said electrode comprises a carbon fiber microelectrode (CFM).

8. The deep brain stimulation system of claim 7, wherein a length of said CFM is about 100 micrometers and a diameter of said CFM is about 5 micrometers.

9. The deep brain stimulation system of claim 1, wherein said electrode is configured to apply said electrical stimulus to said region of said brain tissue using a voltage scan.

10. The deep brain stimulation system of claim 9, wherein a frequency of said voltage scan is 10 Hertz.

11. The deep brain stimulation system of claim 1, further comprising an accelerometer that is configured to be fixed to a patient to detect motions of at least a portion of said patient'"'"'s body,

wherein said control unit is configured to receive information from said accelerometer about said detected motions of said at least a portion of said patient'"'"'s body,

wherein said information that said control unit is configured to send to said probe about said level or said timing of electrical stimulus to apply to said region of said brain tissue is determined based at least on said information from said accelerometer about said detected motions of said at least a portion of said patient'"'"'s body.

12. A deep brain stimulation system, comprising:

a probe comprising (i) an electrode configured to apply an electrical stimulus to a region of brain tissue using a fast-scan cyclic voltammetry technique and (ii) a sensor configured to be located in said region of said brain tissue during application of said electrical stimulus and to generate a signal indicative of a detected level of said neurochemical or said ion present in said region of said brain tissue, and

a control unit in communication with said probe, wherein said control unit is configured to receive information from said probe about said detected level of said neurochemical or said ion and is configured to send information to said probe about a level or a timing of electrical stimulus to apply to said region of said brain tissue,

wherein said electrical stimulus comprises a voltage scan, wherein said probe is configured to apply different voltage scans within said region of said brain tissue to detect different neurochemicals or ions.

13. The deep brain stimulation system of claim 12, wherein said control unit is configured (i) to be located externally of a body of a patient and (ii) to communicate via a wireless channel with said probe.

14. The deep brain stimulation system of claim 12, wherein said sensor is configured to detect a neurochemical selected from the group consisting of dopamine, serotonin, adenosine, adenine mono- or tri-phosphate, norepinephrine, GABA, histamine, acetylcholine, glutamate, aspartate, epinephrine, nitric oxide, glycine, tryptamine, phenylethylamine, tyramine, and octopamine.

15. The deep brain stimulation system of claim 12, wherein said electrode comprises a carbon fiber microelectrode (CFM).

16. The deep brain stimulation system of claim 15, wherein a length of said CFM is about 100 micrometers and a diameter of said CFM is about 5 micrometers.

17. A deep brain stimulation system, comprising:

a probe comprising (i) an electrode configured to apply an electrical stimulus to a region of brain tissue using a fast-scan cyclic voltammetry technique and (ii) a sensor configured to be located in said region of said brain tissue during application of said electrical stimulus and to generate a signal indicative of a detected level of said neurochemical or said ion present in said region of said brain tissue, and

a control unit in communication with said probe, wherein said control unit is configured to receive information from said probe about said detected level of said neurochemical or said ion and is configured to send information to said probe about a level or a timing of electrical stimulus to apply to said region of said brain tissue,

wherein said electrode includes multiple independent active areas for detecting different neurochemicals or ions.

18. The deep brain stimulation system of claim 17, wherein said control unit is configured (i) to be located externally of a body of a patient and (ii) to communicate via a wireless channel with said probe.

19. The deep brain stimulation system of claim 17, wherein said sensor is configured to detect a neurochemical selected from the group consisting of dopamine, serotonin, adenosine, adenine mono- or tri-phosphate, norepinephrine, GABA, histamine, acetylcholine, glutamate, aspartate, epinephrine, nitric oxide, glycine, tryptamine, phenylethylamine, tyramine, and octopamine.

20. The deep brain stimulation system of claim 17, further comprising an accelerometer that is configured to be fixed to a patient to detect motions of at least a portion of said patient'"'"'s body,

wherein said control unit is configured to receive information from said accelerometer about said detected motions of said at least a portion of said patient'"'"'s body,

wherein said information that said control unit is configured to send to said probe about said level or said timing of electrical stimulus to apply to said region of said brain tissue is determined based at least on said information from said accelerometer about said detected motions of said at least a portion of said patient'"'"'s body.