Process to prepare treprostinil, the active ingredient in Remodulin®

  • US 9,604,901 B2
  • Filed: 06/30/2015
  • Issued: 03/28/2017
  • Est. Priority Date: 12/17/2007
  • Status: Active Grant
First Claim
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1. A pharmaceutical batch consisting of treprostinil or a salt thereof and impurities resulting from (a) alkylating a benzindene triol, (b) hydrolyzing the product of step (a) to form a solution comprising treprostinil, (c) containing the solution comprising treprostinil from step (b) with a base to form a salt of treprostinil, (d) isolating the salt of treprostinil, and (e) optionally reacting the salt of treprostinil with an acid to form treprostinil, andwherein the pharmaceutical batch contains at least 2.9 g of treprostinil or its salt.

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