Non-enzymatic glucose sensor

• US 9,606,080 B2
• Filed: 09/05/2013
• Issued: 03/28/2017
• Est. Priority Date: 09/06/2012
• Status: Active Grant

• Current Assignee: Amrita Vishwa Vidyapeetham Deemded University
• Original Assignee: Amrita Vishwa Vidyapeetham Deemded University
• Inventors: Thekkedath, Satheesh Babu G., Thiagarajan, Ramachandran, Nair, Bipin G.
• Primary Examiner(s): Noguerola, Alexander
• Application Number:
  US14/019,314
• Publication Number:
  US 20140061044A1
• Time in Patent Office: 1,300 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: G01N 27/30 Electrodes, e.g. test electrodes; Half-cells G01N27/414 takes precedence
• CPC Class Codes: G01N 27/327 Biochemical electrodes , e.g. electrical or mechanical details for in vitro measurements
• CPC Class Codes: G01N 27/3275 Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
• CPC Class Codes: G01N 27/3278 involving nanosized elements, e.g. nanogaps or nanoparticles nanopores G01N33/48721; magnetic beads G01N27/745

Abstract

A non-enzymatic glucose sensor and method for fabricating the sensor are disclosed. The glucose sensor contains at least one non-enzymatic electrode configured to catalyze the electro-oxidation of glucose in preference to other bio-molecules. The surface of the electrode comprises CuO nanoparticles. The sensor shows sensitivity and selectivity exceeding enzyme based devices presently in use.

Claims

1. A device for detecting glucose, comprising:

at least one active electrode configured to catalyze the electro-oxidation of glucose in preference to other bio-molecules;

wherein the active electrode consists essentially of

a slurry coating of CuO nanoparticles and NaOH;

a coating of conductive carbon; and

a coating of silver; and

wherein the active electrode is encapsulated in an insulating film layer in which a sensing window is provided and wherein the device is configured to produce linear response currents of 0.3 to 1 mA when exposed to glucose concentrations in the 3-10 mM range.

2. The device of claim 1, wherein the CuO nanoparticles comprise spherical, CuO nanoparticles.

3. The device of claim 1, wherein the size of the nanoparticles ranges from 5nm to 500 nm.

4. The device of claim 1, wherein the device is further configured to produce linear response currents of 0.1 to 0.3 mA when exposed to glucose concentrations in the 1-3 mM range.