Formulations of guanylate cyclase C agonists and methods of use
DCFirst Claim
Patent Images
1. A method for treating chronic constipation in a human subject comprising orally administering to said human subject a composition consisting of a per unit dose of 3 mg or 6 mg of a peptide consisting of SEQ ID NO:
- 1 wherein the peptide is a [4,12;
7,15] bicycle, an inert low moisture carrier, and a lubricant, and wherein the peptide has a chromatographic purity of no less than 91% after storage for at least three months.
10 Assignments
Litigations
1 Petition
Accused Products
Abstract
The invention provides low-dose formulations of guanylate cyclase-C (“GCC”) agonist peptides and methods for their use. The formulations of the invention can be administered either alone or in combination with one or more additional therapeutic agents, preferably an inhibitor of cGMP-dependent phosphodiesterase or a laxative.
65 Citations
16 Claims
-
1. A method for treating chronic constipation in a human subject comprising orally administering to said human subject a composition consisting of a per unit dose of 3 mg or 6 mg of a peptide consisting of SEQ ID NO:
- 1 wherein the peptide is a [4,12;
7,15] bicycle, an inert low moisture carrier, and a lubricant, and wherein the peptide has a chromatographic purity of no less than 91% after storage for at least three months. - View Dependent Claims (2, 5, 6, 7, 11, 12, 13)
- 1 wherein the peptide is a [4,12;
-
3. A method of treating or alleviating a symptom associated with chronic idiopathic constipation or irritable bowel syndrome in a human subject comprising orally administering to said human subject a composition consisting of a per unit dose of 3 mg or 6 mg of a peptide consisting of SEQ ID NO:
- 1 wherein the peptide is a [4,12;
7,15] bicycle, an inert low moisture carrier, and a lubricant, and wherein the peptide has a chromatographic purity of no less than 91% after storage for at least three months. - View Dependent Claims (4, 8, 9, 10, 14, 15, 16)
- 1 wherein the peptide is a [4,12;
Specification