Formulations of guanylate cyclase C agonists and methods of use

  • US 9,610,321 B2
  • Filed: 09/04/2015
  • Issued: 04/04/2017
  • Est. Priority Date: 09/15/2010
  • Status: Active Grant
First Claim
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1. A method for treating chronic constipation in a human subject comprising orally administering to said human subject a composition consisting of a per unit dose of 3 mg or 6 mg of a peptide consisting of SEQ ID NO:

  • 1 wherein the peptide is a [4,12;

    7,15] bicycle, an inert low moisture carrier, and a lubricant, and wherein the peptide has a chromatographic purity of no less than 91% after storage for at least three months.

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