Impedance measurement process

• US 9,615,766 B2
• Filed: 11/27/2009
• Issued: 04/11/2017
• Est. Priority Date: 11/28/2008
• Status: Expired due to Fees

• Current Assignee: ImpediMed Limited
• Original Assignee: ImpediMed Limited
• Inventors: Gaw, Richelle Leanne
• Primary Examiner(s): Cerioni, Daniel
• Application Number:
  US13/131,859
• Publication Number:
  US 20110313311A1
• Time in Patent Office: 2,692 Days
• Field of Search: 600547
• CPC Class Codes: A61B 2562/066 in a matrix array
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0531 Measuring skin impedance
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/14535 for measuring haematocrit
• CPC Class Codes: A61B 5/4331 of the cervix A61B5/435 takes precedence
• CPC Class Codes: A61B 5/4337 of the vagina

Abstract

Apparatus for use in performing impedance measurements on a subject, the apparatus including a probe having a plurality of electrodes, the probe being configured to allow at least some of the electrodes to be in contact with at least part of the subject and a processing system for, determining at least one first impedance value, measured at a site using a first electrode configuration, determining at least one second impedance value, measured at the site using a second electrode configuration and determining an indicator indicative of the presence, absence or degree of an anomaly using the first and second impedance values.

Claims

1. An apparatus for use in performing impedance measurements on a subject, the apparatus including:

a) a probe having a plurality of electrodes, the probe being configured to allow at least some of the electrodes to be in contact with a site defined by cervical tissue of the subject, the probe including;

i) a probe portion including the plurality of electrodes positioned at an end of the probe portion, the probe portion being shaped to conform to a shape of a vagina and cervix, said probe portion being insertable into the subject to provide for at least a portion of the electrodes to be contactable with cervical tissues; and

,

ii) a handle portion, the probe portion being removably attached to the handle portion allowing the probe portion to be replaced, and the handle portion being configured for allowing the at least some of the electrodes to be positioned in contact with the site; and

,

b) a signal generator for applying drive signals to the subject using drive electrodes;

c) a sensor for determining measured signals using measurement electrodes;

d) a switching device for selectively interconnecting the signal generator and the sensor to the electrodes; and

,

e) a processing system configured to allow impedance measurements to be performed using different electrode configurations by selectively interconnecting the signal generator and the sensor to different electrodes using the switching device, the processing system being configured to;

i) determine at least one first impedance value, measured at a first contacted portion of cervical tissue using a first electrode configuration, the first electrode configuration using a first electrode and a second electrode as drive electrodes and using a third electrode and a fourth electrode as measurement electrodes;

ii) determine at least one second impedance value, measured at the first contacted portion of cervical tissue using a second electrode configuration, the second electrode configuration using the first electrode and the third electrode as drive electrodes and using the second electrode and the fourth electrode as measurement electrodes;

iii) determine a difference between the first and second impedance values; and

,

iv) determine an indicator indicative of the presence, absence or degree of an anomaly using the determined difference.

2. An apparatus according to claim 1, wherein the handle portion includes at least one of:

a) at least part of the processing system;

b) the signal generator;

c) the sensor;

d) the switching device; and

,

e) a capacitance cancelling circuit.

3. An apparatus according to claim 2, wherein the processing system includes a first processing system and a second processing system and wherein at least one of the first and second processing systems is provided in the handle portion.

4. An apparatus according to claim 1, wherein the apparatus includes an electrode array having a number of electrodes provided thereon, and wherein in use, selected ones of the electrodes are used as drive and measurement electrodes.

5. An apparatus according to claim 1, wherein the apparatus includes a capacitance cancelling circuit for cancelling capacitance coupling between first and second electrodes.

6. An apparatus according to claim 5, wherein the capacitance cancelling circuit includes an inverting amplifier for coupling a signal generator output to a sensor input and wherein the inverting amplifier applies a capacitance cancelling signal to the sensor input to thereby cancel any effective capacitance between the first electrode and the second electrode.

7. An apparatus according to claim 6, wherein an inverting amplifier output is coupled to the sensor input via at least one of a resistor and a capacitor, and wherein at least one of the resistor and capacitor are adjustable, thereby allowing a capacitance cancelling signal applied to the sensor input to be controlled.

8. An apparatus according to claim 1, wherein the apparatus includes an input capacitance cancelling circuit for cancelling an effective input capacitance at a sensor input.

9. An apparatus according to claim 8, wherein the apparatus includes a feedback loop for connecting a sensor output to the sensor input, the feedback loop including at least one of a resistor and a capacitor, wherein at least one of the resistor and capacitor are adjustable, thereby allowing a current flow from the sensor output to the sensor input to be controlled, and wherein the feedback loop applies an input capacitance cancelling signal to the sensor input to thereby cancel any effective capacitance at the sensor input.

10. An apparatus according to claim 1, wherein the processing system determines an impedance value for each of at least four electrode configurations.

11. An apparatus according to claim 1, wherein the processing system is configured to:

a) cause at least one drive signals to be applied to the subject;

b) measure at least one induced signal across the subject; and

,

c) determine at least one impedance value using an indication of the drive signal and the induced signal.

12. An apparatus according to claim 1, wherein the processing system is configured to:

a) determine impedance values at a number of different sites; and

,

b) determine an impedance map using the impedance values at each site.

13. An apparatus according to claim 12, wherein the processing system is configured to:

a) determine the presence of an anomaly at any one of the sites; and

,

b) determine the impedance map taking the anomaly into account by at least one of;

i) excluding the site from the impedance map; and

,

ii) modifying the impedance value determined for the site.

14. An apparatus according to claim 1, wherein the processing system is configured to:

a) compare the difference to a reference; and

,

b) determine an anomaly depending on the result of the comparison.

15. An apparatus according to claim 14, wherein the reference is a previously measured difference for the subject.

16. An apparatus according to claim 1, wherein the impedance values are at least one of:

a) measured impedance values; and

,

b) impedance parameter values derived from measured impedance values, wherein the impedance parameter values include at least one of;

i) an impedance at infinite applied frequency (R_∞

);

ii) an impedance at zero applied frequency (R₀); and

,

iii) an impedance at a characteristic frequency (Z_c).

17. An apparatus according to claim 1, wherein the processing system is configured to:

a) cause at least one first impedance value to be measured at the first contacted portion of cervical tissue using a first electrode configuration; and

,

b) cause at least one second impedance value to be measured at the first contacted portion of cervical tissue using a second electrode configuration.

18. An apparatus according to claim 1, wherein the anomaly includes any one or a combination of:

a) a tissue anomaly; and

,

b) an erroneous measurement.