Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes
First Claim
1. A sample analysis cartridge comprising:
- an input tunnel that extends from an aperture, the input tunnel configured to permit insertion of a sample collection device having a distal portion adapted to be exposed to a sample;
a reservoir configured to hold a fluid, the reservoir further configured to receive the sample from the sample collection device;
a piezoelectric transducer that forms at least part of a wall of the reservoir, the piezoelectric transducer configured to emit energy into the reservoir to mix the fluid, the sample, and reagents; and
a shuttle defining a first compartment and a second compartment, the first and second compartment configured to be disposed within the reservoir in a mixing position, wherein the piezoelectric transducer is configured to emit the energy into the reservoir to move the fluid in the reservoir between the first and second compartments to mix the fluid, the sample, and the reagents in the reservoir.
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Accused Products
Abstract
Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.
140 Citations
29 Claims
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1. A sample analysis cartridge comprising:
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an input tunnel that extends from an aperture, the input tunnel configured to permit insertion of a sample collection device having a distal portion adapted to be exposed to a sample; a reservoir configured to hold a fluid, the reservoir further configured to receive the sample from the sample collection device; a piezoelectric transducer that forms at least part of a wall of the reservoir, the piezoelectric transducer configured to emit energy into the reservoir to mix the fluid, the sample, and reagents; and a shuttle defining a first compartment and a second compartment, the first and second compartment configured to be disposed within the reservoir in a mixing position, wherein the piezoelectric transducer is configured to emit the energy into the reservoir to move the fluid in the reservoir between the first and second compartments to mix the fluid, the sample, and the reagents in the reservoir. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification