Method and system for dynamically updating calibration parameters for an analyte sensor

• US 9,629,578 B2
• Filed: 03/26/2016
• Issued: 04/25/2017
• Est. Priority Date: 10/02/2006
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Hayter, Gary Alan, Budiman, Erwin Satrya, Doniger, Kenneth J., Mazza, John Charles
• Primary Examiner(s): JANG, CHRISTIAN YONGKYUN
• Application Number:
  US15/081,843
• Publication Number:
  US 20160206233A1
• Time in Patent Office: 395 Days
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/0015 characterised by features of the telemetry system
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/725 using specific filters therefor, e.g. Kalman or adaptive filters A61B5/316 take precedence

Abstract

Methods and apparatuses for determining an analyte value are disclosed.

Claims

1. A computer-implemented method, comprising:

obtaining a reference data point at a first predetermined time;

receiving a first data at the first predetermined time from an analyte sensor in fluid contact with an interstitial fluid;

calibrating the first data based on the reference data point;

receiving a second data at a second predetermined time from the analyte sensor;

updating the calibrated first data based on the second data; and

calibrating the second data.

2. The method of claim 1, wherein the reference data point includes a blood glucose value.

3. The method of claim 1, wherein the first predetermined time includes a calibration time associated with the calibration of one or more of the first data or the second data.

4. The method of claim 1, wherein the first data and the second data includes a respective one of a monitored analyte value.

5. The method of claim 1, wherein calibrating the first data includes:

determining a first rate of change of the first data at the first predetermined time; and

performing a first lag compensation of the first data based on the first rate of change to generate a first lag compensated first data.

6. The method of claim 5, wherein calibrating the first data further includes:

determining a first calibration parameter associated with the first data based on the reference data point and the first lag compensated first data; and

generating a calibrated first data based on the first calibration parameter and the first lag compensated first data.

7. The method of claim 5, wherein updating the calibrated first data includes:

determining a second rate of change of the first data at the first predetermined time based on the second data; and

performing a second lag compensation of the first data based on the second rate of change of the first data to generate a second lag compensated first data.

8. The method of claim 7, wherein calibrating the second data includes:

determining a second calibration parameter associated with the first data based on the reference data point and the second lag compensated first data; and

generating a calibrated second data based on the second calibration parameter and the second lag compensated first data.

9. An apparatus, comprising:

one or more processors; and

a memory for storing instructions which, when executed by the one or more processors, causes the one or more processors to obtain a reference data point at a first predetermined time, receive a first data at the first predetermined time from an analyte sensor in fluid contact with an interstitial fluid, calibrate the first data based on the reference data point;

receive a second data at a second predetermined time from the analyte sensor;

update the calibrated first data based on the second data; and

calibrate the second data.

10. The apparatus of claim 9, wherein the reference data point includes a blood glucose value.

11. The apparatus of claim 9, wherein the first predetermined time includes a calibration time associated with the calibration of one or more of the first data or the second data.

12. The apparatus of claim 9, wherein the first data and the second data includes a respective one of a monitored analyte value.