Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods
First Claim
1. A method of testing the surface area characteristics of an electroplated electrode of an electrochemical glucose sensor, comprising:
- performing an electrochemical impedance spectroscopy (EIS) procedure to obtain a value of an impedance-related parameter for said glucose sensor electrode, wherein the impedance-related parameter is imaginary impedance;
correlating said obtained value to said glucose sensor electrode'"'"'s electrochemical surface area;
based on said correlation, determining lower and upper threshold values for said value of the imaginary impedance; and
determining whether the glucose sensor electrode is acceptable for measuring glucose in a body of a subject, wherein said determination is made based on whether said value of the imaginary impedance falls within said lower and upper threshold values and is indicative of a number of low start-up events for the glucose sensor that is below a low start-up event threshold.
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Abstract
A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.
127 Citations
10 Claims
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1. A method of testing the surface area characteristics of an electroplated electrode of an electrochemical glucose sensor, comprising:
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performing an electrochemical impedance spectroscopy (EIS) procedure to obtain a value of an impedance-related parameter for said glucose sensor electrode, wherein the impedance-related parameter is imaginary impedance; correlating said obtained value to said glucose sensor electrode'"'"'s electrochemical surface area; based on said correlation, determining lower and upper threshold values for said value of the imaginary impedance; and determining whether the glucose sensor electrode is acceptable for measuring glucose in a body of a subject, wherein said determination is made based on whether said value of the imaginary impedance falls within said lower and upper threshold values and is indicative of a number of low start-up events for the glucose sensor that is below a low start-up event threshold. - View Dependent Claims (2, 3, 4, 5)
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6. A method of testing the surface area characteristics of an electroplated electrode of an electrochemical glucose sensor, comprising:
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performing an electrochemical impedance spectroscopy (EIS) procedure to obtain a value of an impedance-related parameter for said glucose sensor electrode, wherein the impedance-related parameter is imaginary impedance; correlating said obtained value to said glucose sensor electrode'"'"'s electrochemical surface area; based on said correlation, determining lower and upper threshold values for said value of the imaginary impedance; and determining whether the glucose sensor electrode is acceptable for measuring glucose in a body of a subject, wherein said determination is made based on whether said value of the imaginary impedance falls within said lower and upper threshold values and is indicative of a level of glucose sensor responsiveness that is above a sensor responsiveness threshold. - View Dependent Claims (7, 8, 9, 10)
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Specification