Implantable tissue perfusion sensing system and method

• US 9,636,059 B2
• Filed: 09/13/2012
• Issued: 05/02/2017
• Est. Priority Date: 02/28/2007
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Cinbis, Can, Carney, James K.
• Primary Examiner(s): Skibinsky, Anna
• Application Number:
  US13/612,967
• Publication Number:
  US 20130018233A1
• Time in Patent Office: 1,692 Days
• Field of Search: None
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/361 Detecting fibrillation
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61B 5/7214 using signal cancellation, e.g. based on input of two identical physiological sensors spaced apart, or based on two signals derived from the same sensor, for different optical wavelengths
• CPC Class Codes: A61N 1/3925 Monitoring; Protecting

Abstract

A medical device for sensing cardiac events that includes a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, updates, for each of the plurality of wavelengths, a first normalization coefficient and a second normalization coefficient in response to the detected emitted light, and adjusts the determined plurality of light measurements in response to the first normalization coefficient and the second normalization coefficient.

Claims

1. A medical device for sensing cardiac events, comprising:

a plurality of light sources capable of emitting light at a plurality of wavelengths;

a detector to detect the emitted light; and

a processor configured to;

determine a plurality of light measurements in response to the emitted light detected by the detector,

update, for each of the plurality of wavelengths, a first normalization coefficient and a second normalization coefficient in response to the detected emitted light,

adjust the determined plurality of light measurements in response to the first normalization coefficient and the second normalization coefficient,

determine a change in tissue perfusion using the adjusted plurality of light measurements, and

initiate delivery of an electrical stimulation therapy responsive to the determined change in tissue perfusion,

wherein the first normalization coefficient corresponds to peak-to-peak changes in the plurality of light measurements and the second normalization coefficient corresponds to average amplitudes of the plurality of light measurements,

wherein the processor determines a first baseline associated with the first normalization coefficient and a second baseline associated with the second normalization coefficient, and

wherein the processor is configured to update the first normalization coefficient in response to a ratio of the first baseline and an average of the peak-to-peak changes in the plurality of light measurements and is configured to update the second normalization coefficient in response to a difference between a product of the previously updated first normalization coefficient and a current average amplitude and the second baseline; and

an cardioversion defibrillator communicatively coupled to the processor to deliver the electrical stimulation therapy responsive to the processor'"'"'s initiation thereof.

2. The device of claim 1, further comprising a timing unit configured to determine when to update the first normalization coefficient and the second normalization coefficient dependent on a time period since initiation of the device.

3. The device of claim 2, wherein the timing unit determines timing of a next update in response to relative changes between a current update of the first normalization coefficient and the second normalization coefficient and a previous update of the first normalization coefficient and second normalization coefficient.

4. The device of claim 1, further comprising an activity sensor configured to sense a physical mode of a patient, wherein the processor is further configured to update the first normalization coefficient and the second normalization coefficient in response to the sensed physical mode.

5. The device of claim 4, wherein the physical mode corresponds to walking, and wherein the first normalization coefficient corresponds to vibration amplitudes associated with the plurality of light measurements and the second normalization coefficient corresponds to average pulse amplitudes associated with the plurality of light measurements.

6. The device of claim 5, wherein the processor is configured to determine a first baseline associated with the first normalization coefficient and a second baseline associated with the second normalization coefficient, and wherein the processor is configured to update the first normalization coefficient in response to a ratio of the first baseline and a current vibration amplitude, and the processor is configured to update the second normalization coefficient in response to a difference between a product of the previously updated first normalization coefficient and a current average amplitude and the second baseline.

7. The device of claim 6, wherein the processor is configured to adjust a current light measurement of the plurality of light measurements in response to a difference between a product of the current updated first normalization coefficient and a current light measurement of the plurality of light measurements and the current updated second normalization coefficient.

8. The device of claim 1, wherein the processor is configured to adjust a current light measurement of the plurality of light measurements in response to a difference between a product of the current updated first normalization coefficient and the current light measurement and the current updated second normalization coefficient.

9. The device of claim 1, wherein:

the plurality of light sources comprises an isobestic wavelength light source so that the plurality of light measurements determined by the processor comprises an isobestic light measurement; and

the processor is configured to;

determine the first normalization coefficient and the second normalization coefficient for the isobestic light measurement;

adjust the isobestic light measurement in response to the first normalization coefficient and the second normalization coefficient determined for the isobestic light measurement, and

determine the change in tissue perfusion by determining a blood volume index from at least the adjusted isobestic light measurement.

10. The device of claim 9, wherein:

the plurality of light sources further comprises a red wavelength light source so that the plurality of light measurements determined by the processor comprises a red light measurement; and

the processor is further configured to;

determine the first normalization coefficient and the second normalization coefficient for the red light measurement;

adjust the red light measurement in response to the first normalization coefficient and the second normalization coefficient determined for the red light measurement, and

determine the change in tissue perfusion by determining an oxygen index using at least the adjusted red light measurement and the blood volume index.

11. The device of claim 10, wherein:

the plurality of light sources further comprises a third wavelength light source so that the plurality of light measurements determined by the processor comprises a third light measurement;

the processor is further configured to;

determine the first normalization coefficient and the second normalization coefficient for the third light measurement;

adjust the third light measurement in response to the first normalization coefficient and the second normalization coefficient determined for the third light measurement, and

determine the change in tissue perfusion by determining an oxygen index using the adjusted red light measurement, the adjusted third light measurement and the blood volume index.

12. The device of claim 1, wherein the detected physiologic condition is a tachyarrhythmia and the electrical stimulation therapy is a cardioversion-defibrillation shock.