Enhancing perfusion by contraction

• US 9,649,487 B2
• Filed: 08/16/2013
• Issued: 05/16/2017
• Est. Priority Date: 08/05/2010
• Status: Active Grant

• Current Assignee: Enopace Biomedical Ltd.
• Original Assignee: Enopace Biomedical Ltd.
• Inventors: Dagan, Amir, Reisner, Yotam, Glasberg, Offer, Hanani, Nitai, Ariav, Gal, Gross, Yossi
• Primary Examiner(s): Bertram, Eric D.
• Application Number:
  US13/968,868
• Publication Number:
  US 20130338748A1
• Time in Patent Office: 1,369 Days
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0514 Electrodes for the urinary tract
• CPC Class Codes: A61N 1/0521 Genital electrodes
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/36564 controlled by blood pressure

Abstract

Apparatus and methods are described including a mechanical support element that is placed inside a first vein of a subject. At least one electrode disposed on the mechanical support element is placed inside the first vein, in a vicinity of a site upstream of a bifurcation with a second vein of the subject. A control unit enhances downstream blood flow from the first vein by driving the at least one electrode to divert blood downstream into the second vein by constricting the first vein at the upstream site, by driving the at least one electrode to apply a current to the vicinity of the site. The mechanical support element prevents the first vein from collapsing by providing mechanical support to the vein. Other embodiments are also described.

Claims

1. Apparatus, comprising:

a mechanical support element having a proximal portion and a distal portion, both portions configured to be placed inside a blood vessel of a subject;

a first set of electrodes, disposed in series along the proximal portion of the support element, each electrode disposed at a longitudinal distance from an adjacent one of the electrodes that is less than 30 mm;

a second set of electrodes, disposed in series along the distal portion of the support element, each electrode in the second set of electrodes disposed at a longitudinal distance, from an adjacent electrode in the second set of electrodes, that is less than 30 mm,

a distal-most electrode in the first set of electrodes and a proximal-most electrode in the second set of electrodes being disposed along the support element at a longitudinal distance from one another of more than 1 cm,

the mechanical support element being configured to support the first and second sets of electrodes inside the blood vessel, such that the first and second sets of electrodes are brought into direct contact with a wall of the blood vessel; and

a control unit configured to drive current into the blood vessel wall via the first and second sets of electrodes,

wherein the blood vessel includes a first blood vessel, from which a second blood vessel bifurcates at a bifurcation, and wherein the mechanical support element is configured to bring the first set of electrodes into contact with the blood vessel wall on a first side of the bifurcation, and to bring the second set of electrodes into contact with the blood vessel wall on a second side of the bifurcation, and

wherein the control unit is configured to divert blood from the first blood vessel to the second blood vessel, by driving the current into the blood vessel wall via the first and second sets of electrodes.

2. The apparatus according to claim 1, wherein a diameter of the support element is less than 35 mm.

3. The apparatus according to claim 1, wherein the support element comprises a catheter.

4. The apparatus according to claim 1, wherein the support element comprises a wire frame.

5. The apparatus according to claim 1, wherein the control unit is configured to divert blood from the first blood vessel to the second blood vessel, by generating waves of contraction in the blood vessel wall, by driving the current into the blood vessel wall via the first and second sets of electrodes.