Compositions and methods for teeth whitening

• US 9,655,829 B2
• Filed: 01/26/2016
• Issued: 05/23/2017
• Est. Priority Date: 09/14/2012
• Status: Active Grant

• Current Assignee: Bausch Health Cos., Inc.
• Original Assignee: Valeant Pharmaceuticals International Incorporated (Bausch Health Cos., Inc.)
• Inventors: Loupis, Nikolaos, Piergallini, Remigio
• Primary Examiner(s): WEBB, WALTER E
• Application Number:
  US15/006,943
• Publication Number:
  US 20160136075A1
• Time in Patent Office: 483 Days
• Field of Search: 424 53
• CPC Class Codes: A61K 2800/42 Colour properties
• CPC Class Codes: A61K 2800/434 Luminescent, Fluorescent; Optical brighteners; Photosensitizers
• CPC Class Codes: A61K 2800/48 Thickener, Thickening system
• CPC Class Codes: A61K 2800/52 Stabilizers
• CPC Class Codes: A61K 2800/81 Preparation or application process involves irradiation
• CPC Class Codes: A61K 8/22 Peroxides; Oxygen; Ozone
• CPC Class Codes: A61K 8/42 Amides
• CPC Class Codes: A61K 8/498 having 6-membered rings or their condensed derivatives, e.g. coumarin
• CPC Class Codes: A61N 2005/0606 Mouth
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

Disclosed herein are teeth whitening compositions generally including an oxidizing agent, and an activating agent that has an emission wavelength between about 400 nm and about 570 nm. Methods of employing these compositions to whiten teeth, methods of making these compositions and kits that include some or part of the composition ingredients, are also described.

Claims

1. A method for whitening teeth comprising:

applying a composition comprising an oxidizing agent and at least two chromophores to at least one tooth; and

exposing the composition on the at least one tooth to actinic light;

wherein the at least two chromophores comprise Fluorescein and Eosin Y, each in an amount of 0.001% to 1% by weight of composition.

2. The method of claim 1, wherein each of the at least one tooth is exposed to the actinic light for an amount of time selected from the group consisting of about 1 second to about 30 seconds, about 3 seconds to about 10 seconds, and about 5 seconds to about 10 seconds.

3. The method of claim 1, wherein the oxidizing agent is selected from a group consisting of hydrogen peroxide, carbamide peroxide, and a combination thereof.

4. The method of claim 3, wherein the hydrogen peroxide is less than or equal to 6% by weight of the composition.

5. The method of claim 3, wherein the carbamide peroxide is less than or equal to 22% by weight of the composition.

6. The method of claim 1, wherein the oxidizing agent is in an amount equivalent to a hydrogen peroxide content of about 6% by weight of the composition.

7. The method of claim 1, wherein the at least two chromophores further comprises a chromophore selected from a group consisting of Rose Bengal, Erythrosine, and any combination thereof.

8. The method of claim 1, wherein the composition further comprises a stabilizing agent, a thickening agent, a hydrophilic gelling agent, a base, or a combination thereof.

9. The method of claim 8, wherein the thickening agent is selected from a group consisting of silicon dioxide and fumed silica.

10. The method of claim 8, wherein the hydrophilic gelling agent is selected from a group consisting of polypropylene glycol, polyethylene glycol, propylene glycol, glycerol, a large molecular weight polyol, and a combination thereof.

11. The method of claim 8, wherein the base is potassium hydroxide.

12. The method of claim 1, wherein the pH of the composition is between 2 and 10.

13. The method of claim 1, wherein the at least two chromophores further comprises Rose Bengal.

14. The method of claim 13, wherein the Rose Bengal in an amount of 0.001% to 1% by weight of the composition.

15. The method of claim 1, wherein the at least two chromophores further comprises Erythrosine.

16. The method of claim 15, wherein the Erythrosine in an amount of 0.001% to 1% by weight of the composition.